Marine-Derived Metabolites as Antimalarial Candidates Targeting Various Life Stages
Negm, W., Kabbash, A., Ezzat, S., Zayed, A. (2022). Marine-Derived Metabolites as Antimalarial Candidates Targeting Various Life Stages. EKB Journal Management System, 3(1), 12-18. doi: 10.21608/jampr.2022.125225.1023
Walaa Negm; Amal Kabbash; Shahira M. Ezzat; Ahmed Zayed. "Marine-Derived Metabolites as Antimalarial Candidates Targeting Various Life Stages". EKB Journal Management System, 3, 1, 2022, 12-18. doi: 10.21608/jampr.2022.125225.1023
Negm, W., Kabbash, A., Ezzat, S., Zayed, A. (2022). 'Marine-Derived Metabolites as Antimalarial Candidates Targeting Various Life Stages', EKB Journal Management System, 3(1), pp. 12-18. doi: 10.21608/jampr.2022.125225.1023
Negm, W., Kabbash, A., Ezzat, S., Zayed, A. Marine-Derived Metabolites as Antimalarial Candidates Targeting Various Life Stages. EKB Journal Management System, 2022; 3(1): 12-18. doi: 10.21608/jampr.2022.125225.1023

Marine-Derived Metabolites as Antimalarial Candidates Targeting Various Life Stages

Journal of Advanced Medical and Pharmaceutical Research
Article 2, Volume 3, Issue 1, April 2022, Page 12-18  XML PDF (478.19 K)
Document Type: Review Article
DOI: 10.21608/jampr.2022.125225.1023
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Authors
Walaa Negmorcid 1; Amal Kabbashorcid 1; Shahira M. Ezzatorcid 2; Ahmed Zayed email orcid 1
1Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta 31111, Egypt
2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt
Abstract
Malaria is still a major public health issue in several areas around the world. Due to Plasmodium falciparum's extensive resistance to practically all frontline treatments, massive attempts to combat malaria have been significantly hampered. The search for novel molecules in the sea organisms could lead to new therapies, including malaria. They are desperately needed to address the rise in resistance. Secondary metabolites produced by marine-derived species are structurally new and biologically potent, and they have become intriguing and valuable resources for drug discovery. Among more than 30,000 marine-derived compounds, numerous metabolites belonging to various chemical classes have shown potential efficacy against malaria. They include alkaloids, polyketides, steroids, terpenoids, peptides, and others. The current article presents concise and updated advances highlighting the potential candidates, particularly those isolated from marine sponges and cyanobacteria targeting the different stages of the malarial life cycle for disease management. Hence, this research can open novel resources of bioactive compounds for novel candidates for malaria management and other vector-borne diseases and exploring the oceans and seas treasures, where one-half of the global biodiversity exists.
Keywords
Cyanobacteria; Malaria; Marine products; Plasmodium falciparum; Sponge
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