Kinetics and mechanism of the oxidation of chromium (III) complex involving the antifibrinolytic drug Tranexamic acid by periodate
Mahmoud, S., Taha, M., Khaled, E., Abdel-khalek, A., Mohamed, R. (2023). Kinetics and mechanism of the oxidation of chromium (III) complex involving the antifibrinolytic drug Tranexamic acid by periodate. EKB Journal Management System, 66(1), 521-530. doi: 10.21608/ejchem.2022.125128.5563
Shimaa A. Mahmoud; Mohamed Taha; Eman S. H. Khaled; Ahmed A. Abdel-khalek; Reham A. Mohamed. "Kinetics and mechanism of the oxidation of chromium (III) complex involving the antifibrinolytic drug Tranexamic acid by periodate". EKB Journal Management System, 66, 1, 2023, 521-530. doi: 10.21608/ejchem.2022.125128.5563
Mahmoud, S., Taha, M., Khaled, E., Abdel-khalek, A., Mohamed, R. (2023). 'Kinetics and mechanism of the oxidation of chromium (III) complex involving the antifibrinolytic drug Tranexamic acid by periodate', EKB Journal Management System, 66(1), pp. 521-530. doi: 10.21608/ejchem.2022.125128.5563
Mahmoud, S., Taha, M., Khaled, E., Abdel-khalek, A., Mohamed, R. Kinetics and mechanism of the oxidation of chromium (III) complex involving the antifibrinolytic drug Tranexamic acid by periodate. EKB Journal Management System, 2023; 66(1): 521-530. doi: 10.21608/ejchem.2022.125128.5563

Kinetics and mechanism of the oxidation of chromium (III) complex involving the antifibrinolytic drug Tranexamic acid by periodate

Egyptian Journal of Chemistry
Volume 66, Issue 1, January 2023, Page 521-530  XML PDF (905.46 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.125128.5563
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Authors
Shimaa A. Mahmoud1; Mohamed Tahaorcid 2; Eman S. H. Khaled3; Ahmed A. Abdel-khalek3; Reham A. Mohamed email orcid 3
1Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
2Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt.
3Chemistry department, faculty of science, Beni-Suef university, Beni-Suef, Egypt
Abstract
Tranexamic acid (TXA) have antifibrinolytic properties and finds wide applications in pharmaceuticals, most used in cardiac, orthopaedic, urological, gynaecological, and obstetric surgery. Complexes of tranexamic acid with some metal ions show antimicrobial and anti-tumor activity. Oxidation-kinetic study is of much importance in understanding the mechanistic profile of Cr-TXA complex in biological systems. Kinetics of oxidation of [CrIII(TXA)(H2O)5]2+ by periodate has been spectrophotometrically studied under pseudo order conditions over 293-313 K, pH (3.20-4.20) range, and ionic strength of 0.30 M for a set of periodate concentrations. The initial oxidation product is certainly Cr(V). The reaction is first order dependent on complex concentration. The pseudo-first order rate constant, kobs increased with decreasing proton concentration, indicating that the deprotonated form of the chromium (III) complex is the reactive species. An inner sphere mechanism has been proposed for the oxidation process. The thermodynamic activation parameters are also reported.
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