Protective Role of Curcumin Against Combined Toxicity of Nickel-Chromium on The Enzymatic Antioxidants, Blood and Testicular Histopathology of Albino Rats
El-Amawy, A., Zaahkouk, S., AbdelRasheed, H., Elaraby, B. (2022). Protective Role of Curcumin Against Combined Toxicity of Nickel-Chromium on The Enzymatic Antioxidants, Blood and Testicular Histopathology of Albino Rats. EKB Journal Management System, 65(131), 279-289. doi: 10.21608/ejchem.2022.117929.5316
Ayman Ahmed El-Amawy; Samir Attia Zaahkouk; Hesham Gamal AbdelRasheed; Bassem Elsayed Elaraby. "Protective Role of Curcumin Against Combined Toxicity of Nickel-Chromium on The Enzymatic Antioxidants, Blood and Testicular Histopathology of Albino Rats". EKB Journal Management System, 65, 131, 2022, 279-289. doi: 10.21608/ejchem.2022.117929.5316
El-Amawy, A., Zaahkouk, S., AbdelRasheed, H., Elaraby, B. (2022). 'Protective Role of Curcumin Against Combined Toxicity of Nickel-Chromium on The Enzymatic Antioxidants, Blood and Testicular Histopathology of Albino Rats', EKB Journal Management System, 65(131), pp. 279-289. doi: 10.21608/ejchem.2022.117929.5316
El-Amawy, A., Zaahkouk, S., AbdelRasheed, H., Elaraby, B. Protective Role of Curcumin Against Combined Toxicity of Nickel-Chromium on The Enzymatic Antioxidants, Blood and Testicular Histopathology of Albino Rats. EKB Journal Management System, 2022; 65(131): 279-289. doi: 10.21608/ejchem.2022.117929.5316

Protective Role of Curcumin Against Combined Toxicity of Nickel-Chromium on The Enzymatic Antioxidants, Blood and Testicular Histopathology of Albino Rats

Egyptian Journal of Chemistry
Volume 65, Issue 131, December 2022, Page 279-289  XML PDF (409.99 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.117929.5316
View on SCiNiTO View on SCiNiTO
Authors
Ayman Ahmed El-Amawy email orcid 1; Samir Attia Zaahkouk2; Hesham Gamal AbdelRasheed2; Bassem Elsayed Elaraby3
1Holding Company for Water and Waastewater - Gharbia Branch, Tanta
2Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
3Zoology Department, Faculty Of Science, Al-Azhar University, Cairo, Egypt
Abstract
Recently, in particular, environmental contaminants have continued to be the most potential cause of many diseases, those of toxic metals which are capable of accumulating within vital organs of both humans and animals, inducing reactive oxygen species (ROS) production and causing severe health hazards within biological systems. Nickel (Ni) and chromium (Cr) are toxic elements producing highly reactive radicals which are able to disable enzymatic antioxidants through binding to their active sites. The present study has been designed to evaluate the protective role of curcumin against testicular dysfunction induced by nickel-chromium combination. The concentrations of Ni and Cr as well as the activities of antioxidants endogenous enzymes including; glutathione peroxidase (Gpx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) were all determined in the testicular tissue while hematological biomarkers were being measured in the blood of experimental rats. Mixture metals resulted in significant variances within testicular tissues. However, oral administration of curcumin provided a significantly protective role against combined toxicity of nickel-chromium and reduced histopathological alterations due to antioxidant property represented in scavenging and chelating properties as concluded from the present investigations.
Keywords
heavy metals; curcumin; testicular histopathology; antioxidants; oxidative stress; ROS
Statistics
Article View: 565
PDF Download: 156