Synthesis and Biological Activity of Chromene Derivatives, chromeno[2,3-d][1,3]oxazine derivatives, and chromeno[2,3-d]pyrimidine derivatives
Yousif, M., Abdelhameed, R., Abu-Hashem, A., Yousif, N. (2023). Synthesis and Biological Activity of Chromene Derivatives, chromeno[2,3-d][1,3]oxazine derivatives, and chromeno[2,3-d]pyrimidine derivatives. EKB Journal Management System, 66(1), 113-120. doi: 10.21608/ejchem.2022.114873.5214
Mahmoud Nabil Mahmoud Yousif; Reda M. Abdelhameed; Ameen A Abu-Hashem; Nabil M. Yousif. "Synthesis and Biological Activity of Chromene Derivatives, chromeno[2,3-d][1,3]oxazine derivatives, and chromeno[2,3-d]pyrimidine derivatives". EKB Journal Management System, 66, 1, 2023, 113-120. doi: 10.21608/ejchem.2022.114873.5214
Yousif, M., Abdelhameed, R., Abu-Hashem, A., Yousif, N. (2023). 'Synthesis and Biological Activity of Chromene Derivatives, chromeno[2,3-d][1,3]oxazine derivatives, and chromeno[2,3-d]pyrimidine derivatives', EKB Journal Management System, 66(1), pp. 113-120. doi: 10.21608/ejchem.2022.114873.5214
Yousif, M., Abdelhameed, R., Abu-Hashem, A., Yousif, N. Synthesis and Biological Activity of Chromene Derivatives, chromeno[2,3-d][1,3]oxazine derivatives, and chromeno[2,3-d]pyrimidine derivatives. EKB Journal Management System, 2023; 66(1): 113-120. doi: 10.21608/ejchem.2022.114873.5214

Synthesis and Biological Activity of Chromene Derivatives, chromeno[2,3-d][1,3]oxazine derivatives, and chromeno[2,3-d]pyrimidine derivatives

Egyptian Journal of Chemistry
Volume 66, Issue 1, January 2023, Page 113-120  XML PDF (455.03 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.114873.5214
View on SCiNiTO View on SCiNiTO
Authors
Mahmoud Nabil Mahmoud Yousif email 1; Reda M. Abdelhameed2; Ameen A Abu-Hashem3; Nabil M. Yousif3
1Department of Photochemistry, National Research Centre, Cairo, Egypt
2Department of Applied Organic Chemistry, Chemical Industries Research Institute, National Research Centre, Egypt
3Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Cairo, Egypt
Abstract
Chromene derivative 1 reacted with acetyl chloride and chloroacetyl chloride to give compounds 2a,b. Acetyl derivatives 2a,b were heated under reflux in dry xylene to give oxazine derivatives 3a,b which reacted with hydrazine hydrate and hydroxylamine to afford compounds 4a,b and 5a,b respectively. Pyrimidine derivative 4a reacted with xylose and glucose to give compounds 6a,b which were converted to compounds 7a,b by reaction with acetic anhydride. The structure of the prepared derivatives was elucidated through mass spectroscopy, 1H & 13C NMR, infrared spectroscopy and elemental analysis. Anticancer activity of some of prepared compounds was performed against three different cancer cell lines.
Keywords
chromene; chromeno[2; 3-d][1; 3]oxazin; oxazine; anticancer activity
Statistics
Article View: 580
PDF Download: 240