AFLATOXIN B1 INDUCED RENAL TOXICITY IN RATS AND THE AMELIORATIVE ROLE OF VITAMIN A | ||||
| Egyptian Journal of Zoology | ||||
| Article 14, Volume 67, Issue 67, June 2017, Page 247-266 | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.12816/0037845 | ||||
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| Author | ||||
Hanan M. Abd El-Latief 
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| Zoology Department, Women’s College for Arts, Science &Education, Ain Shams University, Cairo, Egypt | ||||
| Abstract | ||||
| This study was designed to investigate the possible protective therapeutic dose of vitamin A on kidneys of female rats treated with aflatoxin B1 (AFB1). Animals were divided into 5 equal groups, each group containing 6 rats. Group I: animals served as normal controls. Group 2: animals of this group were orally administered vehicel with vitamin A (132 IU) double the human therapeutic dose. Group 3: animals were orally administered vehicle 50% DMSO alone. Group 4: animals were orally administered 0.05 μg AFB1 per kg dissolved in 50% DMSO (dimethylsulfoxide). Group 5: animals were orally administered 0.05 μg AFB1/kg with vitamin A. The experiment lasted for 14 weeks, and then animals were sacrificed and dissected after 24 hours. Kidney sections of female rats treated with either DMSO or\and AFLB1 individually showed pathological changes represented by vacuolations of epithelial cells of the renal tubules; inflammatory cell infiltration; lobulated glomreuli; hemorrhage; degenerated renal tubules; dilated congested blood vessels and degenerated areas with rupturing in Bowman's capsule and widen Bowman's space, accompanied with pyknotic nuclei of the renal tubule cells. On the histochemical level, data obtained showed significant reduction of protein, DNA and polysaccharides contents in kidney tissues. Vitamin A administration showed a partial improvement of the above mentioned histopathological and histochemical alterations. | ||||
| Keywords | ||||
| Aflatoxin B1; vitamin A; kidney; female rats | ||||
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