Resveratrol protects against early cardiomyopathic changes-induced by Type-1 diabetes through a heme-oxygenase-1 dependent mechanism | ||||
| Journal of advanced Biomedical and Pharmaceutical Sciences | ||||
| Article 3, Volume 2, Issue 1, January 2019, Page 12-18 PDF (1.19 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jabps.2018.5175.1022 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Asmaa S.A. Hammad1; Al-Shaimaa F. Ahmed   1; Gehan H. Heeba1; Ashraf A. Taye1, 2
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| 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt | ||||
| 2Department of Pharmacology & Toxicology, Faculty of Pharmacy, South Valley University, Qena, Egypt | ||||
| Abstract | ||||
| Diabetes can be considered as a state of chronic inflammation and oxidative stress. Excessive oxidative stress is implicated in the pathogenesis of all diabetic complications. Heme oxygenase-1 is an antioxidant enzyme that is upregulated in response to a variety of insults as a protective mechanism. Resveratrol (RSV) is a polyphenol that exhibits promising pharmacological effects in a variety of disease models. In this study, we investigated the role of RSV in prevention of early pathological changes in the diabetic heart as well as the role of hemeoxygenase-1 in this regard. To achieve this aim, diabetes was induced by ip injection of streptozotocin (50 mg/kg). The rats were divided into 5 experimental groups; normal control (CTR), diabetic control (DM), diabetic rats treated with RSV (DM+RSV); 10 mg/kg) in drinking water, diabetic rats treated with a combination of RSV and an HO-1 inhibitor, Zinc protoporphyrin (ZnPP), (DM + RSV+ZnPP); 10 µmole/Kg/week I.P) and diabetic rats treated with ZnPP alone (DM + ZnPP). Induction of diabetes was accompanied by a significant increase in cardiac MDA level and TGF-β protein expression as well as a significant reduction in eNOS and HO-1 expression. Chronic treatment with RSV significantly attenuated the abovementioned biochemical changes associated with diabetes in addition to alleviation of diabetes-induced histopathological alterations. Furthermore, the effect of RSV was diminished when the HO-1 activity was blocked by ZnPP. These results demonstrate the role of HO-1 in mediating RSV protective effects against diabetes-induced early cardiomyopathy. | ||||
| Keywords | ||||
| Resveratrol; Type-1 diabetes; heme-oxygenase-1; cardiomyopathy | ||||
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