Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.
Alobaidi, A., Alsamarai, A. (2023). Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.. EKB Journal Management System, 66(1), 531-543. doi: 10.21608/ejchem.2022.125283.5572
Amina Hamed Alobaidi; Abdulghani Mohamed Alsamarai. "Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.". EKB Journal Management System, 66, 1, 2023, 531-543. doi: 10.21608/ejchem.2022.125283.5572
Alobaidi, A., Alsamarai, A. (2023). 'Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.', EKB Journal Management System, 66(1), pp. 531-543. doi: 10.21608/ejchem.2022.125283.5572
Alobaidi, A., Alsamarai, A. Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.. EKB Journal Management System, 2023; 66(1): 531-543. doi: 10.21608/ejchem.2022.125283.5572

Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.

Egyptian Journal of Chemistry
Volume 66, Issue 1, January 2023, Page 531-543  XML PDF (1.35 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.125283.5572
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Authors
Amina Hamed Alobaidiorcid 1; Abdulghani Mohamed Alsamarai email orcid 2
1Department of Biochemistry, College of Medicine, Kirkuk University, Kirkuk, Iraq
2Department of Medicine, College of Medicine, Tikrit University, Tikrit, Iraq
Abstract
To clarify the role of TNF-α, IL-18, osteopontin, lipoprotein (a) and paraoxonase in psoriasis in Iraqi community this study was conducted. Cross-sectional study included 94 subjects with psoriasis vulgaris, with a mean age of 37.5 ± 11.6 year. Serum osteopontin, IL-18 and TNF-α were determined using Enzyme linked immunosorbent assay kits. The mean serum levels of TNF-α, IL-18, OPN, and LP (a) were significantly higher in individuals with psoriasis as compared to controls. In contrast, PON 1 mean serum value was significantly lower in psoriasis compared to controls. Odd ratio indicated a significant association between increase in TNF-α, IL-18, OPN and Lp(a) and the decrease in PON1 in our cohort study. Disease severity significantly correlated with serum levels of TNF-α, IL-18 and Lp (a), while inversely correlated with serum levels of PON 1. TNF-α was with high predictivity in monitoring psoriasis severity and response to treatment. The elevation of serum IL-18, OPN, LP(a) and reduction of PON1 indicated that these biomarkers may play a role in psoriasis pathogenesis. The significant correlation of serum levels of TNF-α, IL-18 and LP (a) with PASI and inverse correlation of PON1 with PASI are useful biomarkers for monitoring of disease severity and treatment outcome.
Keywords
Psoriasis; TNF-α IL-18; osteopontin; lipoprotein; paraoxonase
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