Comorbidity Index in Predicting Toxicity and Mortality Risk among patient Undergoing Hematopoietic Stem Cell Transplantation
Abdelkader Abdelfattah, S., Mohamed Safwat, A., El-dein Mohamed, G., Mohamed Maarouf, D. (2022). Comorbidity Index in Predicting Toxicity and Mortality Risk among patient Undergoing Hematopoietic Stem Cell Transplantation. EKB Journal Management System, 13(1), 1638-1650. doi: 10.21608/ejhc.2022.231283
Sara Abdelkader Abdelfattah; Amany Mohamed Safwat; Gamal El-dein Mohamed; Dina Mohamed Maarouf. "Comorbidity Index in Predicting Toxicity and Mortality Risk among patient Undergoing Hematopoietic Stem Cell Transplantation". EKB Journal Management System, 13, 1, 2022, 1638-1650. doi: 10.21608/ejhc.2022.231283
Abdelkader Abdelfattah, S., Mohamed Safwat, A., El-dein Mohamed, G., Mohamed Maarouf, D. (2022). 'Comorbidity Index in Predicting Toxicity and Mortality Risk among patient Undergoing Hematopoietic Stem Cell Transplantation', EKB Journal Management System, 13(1), pp. 1638-1650. doi: 10.21608/ejhc.2022.231283
Abdelkader Abdelfattah, S., Mohamed Safwat, A., El-dein Mohamed, G., Mohamed Maarouf, D. Comorbidity Index in Predicting Toxicity and Mortality Risk among patient Undergoing Hematopoietic Stem Cell Transplantation. EKB Journal Management System, 2022; 13(1): 1638-1650. doi: 10.21608/ejhc.2022.231283

Comorbidity Index in Predicting Toxicity and Mortality Risk among patient Undergoing Hematopoietic Stem Cell Transplantation

Egyptian Journal of Health Care
Article 111, Volume 13, Issue 1, March 2022, Page 1638-1650  XML PDF (1.49 MB)
Document Type: Original Article
DOI: 10.21608/ejhc.2022.231283
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Authors
Sara Abdelkader Abdelfattah1; Amany Mohamed Safwat2; Gamal El-dein Mohamed3; Dina Mohamed Maarouf4
1Demonstrator in Critical Care Nursing, Faculty of Nursing- Ain Shams University, Egypt
2Professor in Critical Care Nursing, Faculty of Nursing- Ain Shams University, Egypt
3Professor in Hematology and bone marrow transplantation, Nasser Institute for Research and Treatment, Egypt
4Lecturer in Critical Care Nursing, Faculty of Nursing- Ain Shams University, Egypt
Abstract
Abstract: Despite current improvement in supportive care, mortality after hematopoietic stem cell
transplantation remains high. Caring for patients undergoing hematopoietic stem cell transplantation
is one of the most challenging in nursing subspecialities. Aim: Assess comorbidity index in predicting
toxicity and mortality risk among patient undergoing hematopoietic stem cell transplantation through:
assess comorbidities of patient’s pre-hematopoietic stem cell transplantation, assess toxicity and
mortality risk post hematopoietic stem cell transplantation & assess the relation of pre-transplantation
comorbidity scores and post transplantation-related toxicity and mortality in patients undergoing
hematopoietic stem cell Transplantation. Study design: A descriptive retrospective design was
utilized to conduct this study. Subject: A purposive sample of (44) patients undergoing allogeneic
hematopoietic stem cell transplantation was recruited in this study. Setting: This study conducted at
The Bone Marrow Transplantation Unit in Nasser institute for research and treatment. Tools: Tool I.
Patient structured interview questionnaire, Tools II. The hematopoietic stem cell transplantation
specific-comorbidity index (HCT-CI) & Tools III Seattle Criteria for Organ Toxicity after Bone
Marrow Transplantation. Results: The study revealed that there was a positive correlation between
comorbidity, organ toxicity and total mortality post bone marrow transplantation with p value 0.01.
Conclusion: Comorbidity index is an important tool to predict toxicity and mortality rate among
patient undergoing hematopoietic stem cell transplantation as there was a positive correlation between
patient’s comorbidity (obesity, cerebrovascular disease, cardiac disease, infection, renal disease, prior
malignancy, hepatic disease and psychiatric disorder) and total toxicity and mortality post bone
marrow transplantation. Recommendations: Apply Comorbidity Index in predicting toxicity and
mortality risk among patient undergoing Hematopoietic Stem Cell Transplantation.
Keywords
Comorbidity Index; Hematopoietic Stem Cell Transplantation
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