PROTECTIVE EFFECT OF PLATELET-RICH PLASMA ON CISPLATIN INDUCED NEPHROTOXICITY IN ADULT MALE ALBINO RATS: (HISTOLOGICALAND IMMUNOHISTOCHEMICAL STUDY)
El Agwany, A., Abo Nazel, M., El Sekily, N., Kelada, M., El-Mallah, M. (2022). PROTECTIVE EFFECT OF PLATELET-RICH PLASMA ON CISPLATIN INDUCED NEPHROTOXICITY IN ADULT MALE ALBINO RATS: (HISTOLOGICALAND IMMUNOHISTOCHEMICAL STUDY). EKB Journal Management System, 4(2), 6-7. doi: 10.21608/alexpo.2022.128485.1389
Amany Mahmoud El Agwany; Maha Abo Nazel; Nancy Mohamed Ali El Sekily; Melad Naim Bushra Kelada; Mona Mohammed El-Mallah. "PROTECTIVE EFFECT OF PLATELET-RICH PLASMA ON CISPLATIN INDUCED NEPHROTOXICITY IN ADULT MALE ALBINO RATS: (HISTOLOGICALAND IMMUNOHISTOCHEMICAL STUDY)". EKB Journal Management System, 4, 2, 2022, 6-7. doi: 10.21608/alexpo.2022.128485.1389
El Agwany, A., Abo Nazel, M., El Sekily, N., Kelada, M., El-Mallah, M. (2022). 'PROTECTIVE EFFECT OF PLATELET-RICH PLASMA ON CISPLATIN INDUCED NEPHROTOXICITY IN ADULT MALE ALBINO RATS: (HISTOLOGICALAND IMMUNOHISTOCHEMICAL STUDY)', EKB Journal Management System, 4(2), pp. 6-7. doi: 10.21608/alexpo.2022.128485.1389
El Agwany, A., Abo Nazel, M., El Sekily, N., Kelada, M., El-Mallah, M. PROTECTIVE EFFECT OF PLATELET-RICH PLASMA ON CISPLATIN INDUCED NEPHROTOXICITY IN ADULT MALE ALBINO RATS: (HISTOLOGICALAND IMMUNOHISTOCHEMICAL STUDY). EKB Journal Management System, 2022; 4(2): 6-7. doi: 10.21608/alexpo.2022.128485.1389

PROTECTIVE EFFECT OF PLATELET-RICH PLASMA ON CISPLATIN INDUCED NEPHROTOXICITY IN ADULT MALE ALBINO RATS: (HISTOLOGICALAND IMMUNOHISTOCHEMICAL STUDY)

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Article 1, Volume 4, Issue 2, June 2022, Page 6-7  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2022.128485.1389
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Authors
Amany Mahmoud El Agwany1; Maha Abo Nazel2; Nancy Mohamed Ali El Sekily1; Melad Naim Bushra Kelada1; Mona Mohammed El-Mallah email 1
1Department of Human Anatomy and Embryology, Faculty of Medicine, Alexandria University
2Department of Histology and Cell Biology, Faculty of Medicine, Alexandria University
Abstract
Drug induced nephrotoxicity is the presence of any kidney injury caused by medications.This nephrotoxicity may be manifested as acute kidney injury (AKI), chronic kidney injury (`CKI), or any other clinical renal manifestations. Cisplatin is one of the most common drugs documented to cause nephrotoxicity. It causes nephrotoxicity by many mechanisms. First, it is mainly excreted by the kidney through tubular secretion. Within the tubular cells, cisplatin conjugate with water forming hydrates which cause DNA damage, oxidative stress, and apoptosis. Also, Cisplatin induces renal cell apoptosis via three ways; death receptors exogenous pathway, endoplasmic reticulum stress pathway (ERS), and mitochondria mediated endogenous pathway. Platelet –rich plasma (PRP) is an autologous human plasma. It is a mixture of highly concentrated platelets, growth factors, and bioactive molecules. It may play a major protective role in cases of cIt activates the tissue regeneration through cell proliferation and differentiation cisplatin –induced nephrotoxicity because of its high content of growth factors.
Keywords
acute kidney injury (AKI); chronic kidney injury (`CKI); Platelet –rich plasma (PRP)
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