Value of Urinary Ceruloplasmin as a Marker in Juvenile SLE
Hossny, E., Sharaf, M., Wahba, N., Warsame, A. (2022). Value of Urinary Ceruloplasmin as a Marker in Juvenile SLE. EKB Journal Management System, 20(1), 3-6. doi: 10.21608/ejpa.2022.231501
Elham Hossny; Mohammad Sharaf; Nancy Wahba; Abdulrahman Warsame. "Value of Urinary Ceruloplasmin as a Marker in Juvenile SLE". EKB Journal Management System, 20, 1, 2022, 3-6. doi: 10.21608/ejpa.2022.231501
Hossny, E., Sharaf, M., Wahba, N., Warsame, A. (2022). 'Value of Urinary Ceruloplasmin as a Marker in Juvenile SLE', EKB Journal Management System, 20(1), pp. 3-6. doi: 10.21608/ejpa.2022.231501
Hossny, E., Sharaf, M., Wahba, N., Warsame, A. Value of Urinary Ceruloplasmin as a Marker in Juvenile SLE. EKB Journal Management System, 2022; 20(1): 3-6. doi: 10.21608/ejpa.2022.231501

Value of Urinary Ceruloplasmin as a Marker in Juvenile SLE

The Egyptian Journal of Pediatric Allergy and Immunology
Article 2, Volume 20, Issue 1, April 2022, Page 3-6  XML PDF (529.87 K)
Document Type: Review
DOI: 10.21608/ejpa.2022.231501
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Authors
Elham Hossny email 1; Mohammad Sharaf2; Nancy Wahba3; Abdulrahman Warsame4
1Pediatric Allergy, Immunology and Rheumatology Unit, Children’s Hospital, Ain Shams University;
2Pediatric Nephrology Unit, Children’s Hospital, Ain Shams University;
3Department of Clinical Pathology, Ain Shams University
4Public Health Hospital, Benadir, Somalia
Abstract
Abstract
There is substantial evidence that lupus nephritis (LN) is primarily related to type-III hypersensitivity reactions leading to immune complex deposition at the mesangial, subendothelial, and/or subepithelial space near the renal glomerular basement membrane. The search for a non-invasive urinary marker of lupus nephritis is an appealing point of research. There are few studies that have evaluated the role of urinary ceruloplasmin (CP) as a biomarker for LN. Being expressed at high levels by parietal epithelial cells of Bowman’s capsule it could possibly detoxify molecules as they pass through the glomerular filter. CP is a highly effective antioxidant that can prevent oxidative damage to lipids, DNA, and proteins. However, it is unlikely that a single biomarker can replace clinical parameters to monitor disease progression and detect early renal flares.
Keywords
Juvenile SLE; urinary ceruloplasmin
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