Correlation between Serum Inflammatory and Oxidative Stress Markers with Blood Pressure in Preeclampsia | ||||
Minia Journal of Medical Research | ||||
Volume 32, Issue 2, April 2021, Page 54-66 PDF (411.56 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjmr.2021.231546 | ||||
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Authors | ||||
Amira A. Abdel Fattah1; Akef A. Khowailed2; Safy S. Gaber1 | ||||
1Department of Medical Physiology, Faculty of Medicine, Beni-Suef University, Egypt. | ||||
2Department of Medical Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Egypt. | ||||
Abstract | ||||
Objectives: To evaluate the serum pro-inflammatory cytokines (Tumor necrosis alpha (TNF α)), oxidative stress marker(Malondialdehyde(MDA)) and serum antioxidant biomarker (Superoxide dismutase(SOD)) and study their correlations with blood pressure (BP) in preeclampsia (PE). Methods: Fifty pregnant women (18 - 35 years old) were divided into two groups each with 25 pregnant women: preeclampsia group and control group. Results: Blood pressure, mean serum TNF α, and MDA were significantly higher, while, the mean serum value of SOD was significantly lower in the pregnant women with preeclampsia than in the control pregnant women. Also, there was a significant positive correlation between TNF α, MDA, and BP. Conclusion: Elevated both serum TNF α, MDA and decreased SOD are the possible mechanisms involved in the pathogenesis of PE. Early detection of PE allows for planning of appropriate monitoring of PE and for prevention of complications. | ||||
Keywords | ||||
Preeclampsia; ROS; TNF α; Antioxidants; Oxidative stress | ||||
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