Influence of Short Term Aluminum Treatment on Iron Metabolism in Young and Aged Rats | ||||
| Journal of High Institute of Public Health | ||||
| Article 11, Volume 31, Issue 3, July 2001, Page 597-606 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jhiph.2001.231850 | ||||
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| Authors | ||||
| Yosria El-Sayed1; Azza S. Abdou1; Osama A. Abbas2 | ||||
| 1Department of Physiology, Medical Research Institute, Alexandria University, Egypt | ||||
| 2Department of Biology (Physiology), Faculty of Education, Suez Canal University, Port Said, Egypt | ||||
| Abstract | ||||
| The long term Aluminum [Al] loading of rats is associated with impaired erythropoiesis and iron metabolism. Data are lacking about the effects after short term aluminum treatment. The present work revealed that the 7 day's treatment of Aluminum sulphate Al2 [So4l3 in a dose of 67.5 mg/Kg body weight by intramuscular [I.M] injection significantly decreases serum haemoglobin [Hb], serum iron, total iron binding capacity [TIBC], unsaturated iron binding capacity [U1BC] and serum ferritin, both in young [6 months) and aged [24 months] rats, with higher levels of brain ferritin in the treated groups as compared to their controls. These findings indicate that short term Aluminum treatment probably hinders Hb synthesis and iron metabolism. Obviously, the alterations detected were more pronounced in the aged group than the younger one. So it is recommended that Aluminum containing agents should be used with care in young and elderly individuals. | ||||
| Keywords | ||||
| Influence; Short Term Aluminum Treatment; Iron Metabolism; Young Rats; Aged Rats | ||||
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