Frequency of Metabolic Associated Fatty Liver Disease among Chronic Kidney Disease Patients in Upper Egypt

Bazeed, Shamardan Ezzeldin S.; Fayed, Hanan Mahmoud; Hashim, AbdelKader Ahmed; Abdelhady, Omima Rabea Abdelrady; Arafat, Shimaa

doi:10.21608/svuijm.2022.128484.1299

	Frequency of Metabolic Associated Fatty Liver Disease among Chronic Kidney Disease Patients in Upper Egypt
SVU-International Journal of Medical Sciences
Article 19, Volume 5, Issue 2, July 2022, Page 189-199 PDF (378.19 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2022.128484.1299
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Authors
Shamardan Ezzeldin S. Bazeed ¹; Hanan Mahmoud Fayed ²; AbdelKader Ahmed Hashim ³; Omima Rabea Abdelrady Abdelhady ¹; Shimaa Arafat ¹
¹Department of Tropical Medicine and Gastroenterology Department, Faculty of Medicine, South Valley University, Qena, Egypt.
²Department of Clinical and Chemical Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt.
³Department of Internal Medicine, Faculty of Medicine, South Valley University , Qena, Egypt.
Abstract
Background: Chronic kidney disease (CKD) and metabolic-associated fatty liver disease (MAFLD) are increasing chronic illnesses that contribute to a variety of major cardio-metabolic risk factors and pathogenic processes. Objectives: To estimate the frequency of MAFLD and its risk factors among CKD Patients in Upper Egypt. Patients and methods: a case-control study entangled 200 individuals with CKD and 60 person without as a control. All participants underwent a thorough history, physical examination, and laboratory testing which incorporate complete blood count, assessment of neutrophil-lymphocyte ratio (NLR), liver enzymes (ALT, AST), kidney function, estimated glomerular filtration rate (eGFR), and lipid profile. Pelvic-abdominal ultrasound and fibroscan were executed. Results: We found a significantly increased proportion of MAFLD, HbA1c and NLR values in the cases group when compared with the control group, where a high prevalence of steatosis and liver stiffness among CKD patients. Multivariate logistic regression analysis demonstrated that high BMI, elevated LDL, elevated liver enzymes (AST & ALT) were predictive risk factors for the existence of MAFLD in the CKD patients. Conclusion: There is a statistically significant correlation between CKD and MAFLD in the form of increased prevalence of MAFLD in CKD patients.
Keywords
Metabolic associated fatty liver disease; chronic kidney disease; estimated glomerular filtration


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