Synthesis and Identification of Chiral open-chain sugar-derived nitrones and their 1,3-Dipolar Cycloaddition with maleimide and maleic acid | ||||
| Egyptian Journal of Chemistry and Environmental Health | ||||
| Volume 2, Issue 1, May 2016, Page 64-74 PDF (446.63 K) | ||||
| Document Type: Scientific and Research | ||||
| DOI: 10.21608/ejceh.2016.232411 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Usama S. Altimari* ; Arwa Al.Adroay | ||||
| College of Health and Medical Technology, Baghdad, IRAQ | ||||
| Abstract | ||||
| The chiral open-chain sugar-derived nitrones (a,b) were prepared in a pure form. N-Sugar-derived isoxazolidines (2a,b-3a,b)) were synthesized regiospecifically by 1,3-dipolar cycloaddition reaction of a nitrone (a,b) with maleimide and maleic acid. N-sugar-derived isoxazolidine (3a) showed high activity against staphylococcus aurous, and Escherichia coli and complete inhibition of growth against pathogenic fungi candida albicans and microsporum gypseum | ||||
| Keywords | ||||
| sugar-derived nitrones; 1; 3-dipolar cycloaddition; N-sugarderived isoxazolidines | ||||
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