Formulation and Physicochemical Evaluation of Theophylline Nanoparticles Transdermal Patch | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 65, Issue 132, December 2022, Page 51-57 PDF (576.98 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.114370.5206 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
suryani Suryani   1; Muhamad Handoyo Sahumena2; Waode Sitti Zubaydah3; Sitti Raodah Nurul Jannah3; Sandra Aulia Mardikasari4; Muhammad Aswan5; Septiany Fransisca Maria6; Andi Nafisah Tenri Adjeng 7; Michrun Nisa8
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| 1Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, South East Sulawesi, Indonesia | ||||
| 2Departement of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, South East Sulawesi, Indonesia | ||||
| 3Departement of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, South East Sulawesi, Indonesia | ||||
| 4Departement of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar South Sulawesi, Indonesia | ||||
| 5Pusdaya Indonesia, Kendari, South East Sulawesi, Indonesia | ||||
| 6Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University | ||||
| 7Departement of Pharmacy, Faculty of Medicinal, Lampung University, Lampung, Sumatera, Indonesia | ||||
| 8Departement of Pharmacy, Sekolah Tinggi Ilmu Farmasi Makassar, South Sulawesi, Indonesia | ||||
| Abstract | ||||
| The objectives of this research were to formulate theophylline nanoparticles matrix transdermal patch with different ratios of hydroxypropyl methylcellulose and ethylcellulose polymer with ratio 90%:10% (F1), 80%:20% (F2), 70%:30% (F3), 60%:40% (F4), 50%:50% (F5), and to evaluate the physicochemical characteristic of the resulted matrix patch. Preparation of matrix patch was conducted by the solvent evaporation casting method. Physicochemical characteristics of the patch, including physical appearance, weight uniformity, thickness uniformity, pH, moisture content, tensile strength, and profile release, were evaluated. Permeation of drugs into the skin was assessed using a modified Franz diffusion cell. Observations of the physical appearance showed that matrix patches were transparent, smooth, and dry. Weight uniformity ranges were from 0.69 g to 0.77 g with thickness 0.14 mm to 0.22 mm. Moisture content ranges were 0.49% to 2.14%, and pH values were from 5.0 to 6.0. Tensile strength ranged between 1.19 and 3.41 N/mm2. Theophylline release of F1-F5 formulation was varied from 14.46% to 18.62% at 360 minutes, and all patches were capable of permeating through the rat skin membrane. Physicochemical evaluation of matrix patches showed that all patches fulfill the requirements of acceptable patches for transdermal administration. | ||||
| Keywords | ||||
| Formulation; theophylline nanoparticles; matrix transdermal patch; physicochemical evaluation | ||||
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