Structure Explication, Biological Evaluation, DNA Interaction, Electrochemistry and Antioxidant Activity of Iron (II) tri- and Tetra-Dentate Schiff base Amino Acid Complexes | ||||
| Sohag Journal of Sciences | ||||
| Volume 6, Issue 2, May 2021, Page 9-25 PDF (1.37 MB) | ||||
| Document Type: Regular Articles | ||||
| DOI: 10.21608/sjsci.2021.233178 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed M. Abu-Dief  1; Laila H. Abdel-Rahman1; Nahla Ali Hashem2; Emad F. Newair2
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| 1Chemistry Department, Faculty of Science, Sohag University, Sohag 82534, Egypt | ||||
| 2Chemistry Department, Faculty of Science, Sohag University, Sohag 82534, Egypt. | ||||
| Abstract | ||||
| New azomethine Schiff base amino acid ligands derived from the condensation reaction of 3– methoxysalicylaldehyde (MS) or 4-diethylaminosalicylaldehyde (DS) with some of α-amino acids (L-phenylalanine (Phe), L-histidine (His), DL-tryptophan (Trp)) and their Fe(II) complexes were prepared. Structures of the synthesized Fe(II) complexes were determined on the basis of elemental analysis, infrared, ultraviolet-visible spectra, thermal analysis and cyclic voltammetry (CV) as well as conductivity, magnetic susceptibility measurements. Moreover, the particle size distribution of the prepared complexes was determined by using transmittance electron microscope (TEM). The experimental results show that the investigated Fe(II) complexes contain hydrated water molecules (expect DSPFe complex) and coordinated water molecules (only in MSHFe complex), The kinetic and thermal parameters were determined from the thermal data using Coast and Redfern method,. The results suggest that MS or DS amino acid Schiff bases behave as monobasic tridentate ONO ligands and coordinate to Fe(II) in octahedral geometry according to the general formula [Fe(HL)2].nH2O. But in the case of MSHFe complex, MSH ligand acts as tetradentate ((NH4 + )[Fe(HL)(H2O)SO4] - .2H2O).The conductivity values between 43.30-5.66 Ω-1 mol-1 cm-2 in DMF suggest the presence of non-electrolyte species, except MSHFe complex is electrolyte species (60.3 Ω-1 mol-1 cm-2 ). Moreover, the antimicrobial evaluation of the prepared Schiff base amino acid ligands and their Fe(II) complexes was examined against three types of bacteria such as B. subtilis (+ve), E. coli (-ve) and M. luteus (+ve) and three types of fungi such as A. niger, C. glabrata and S. cerevisiae. The results of these studies signalizing that the metal chelates exhibit a stronger antimicrobial efficiency than their corresponding ligands. Moreover, the interaction of the prepared Fe(II) complexes with (CT-DNA) by using spectral studies, viscosity measurements and agarose gel electrophoresis was investigated. Furthermore, antioxidant activities of the synthesized complexes were examined by using the ABTS assay and showed that the prepared complexes have a good antioxidant activity. | ||||
| Keywords | ||||
| Amino acid; Fe(II) complexes; Antimicrobial; Cyclic voltammetry; antioxidant; DNA interaction | ||||
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