Evaluation of Antidiabetic Activity of Ipomoea Aquatica Fractions in Streptozotocin Induced Diabetic in Male Rat Model N | ||||
| Sohag Journal of Sciences | ||||
| Volume 2, Issue 1, January 2017, Page 9-17 PDF (628.58 K) | ||||
| Document Type: Regular Articles | ||||
| DOI: 10.21608/sjsci.2017.233204 | ||||
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| Authors | ||||
Nagwa El-Sawi  1; Mahmoud Hefny Gad2; Madeha Nooh Al-Seeni3; Sabry Younes1; El-Mewafy El-Ghadban2; Soad Shaker Ali4
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| 1Department of Chemistry, Faculty of Science, Sohag University, Sohag, Egypt. | ||||
| 2Medicinal and Aromatic Plants Research Department, Horticulture Institute, Agriculture Research Center, Dokki, Giza, Egypt. | ||||
| 3Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. | ||||
| 4Histology Department, Faculty of Medicine, King Abdoul Aziz University, Saudi Arabia | ||||
| Abstract | ||||
| Ipomoea aquatica (IA) is a common green leafy vegetable consumed in many parts of the world. The plant is considered as a good antidiabetic herbal plant. The present work was designed to investigate the oral hypoglycaemic activity of Ipomea aquatica fractions in streptozotocin induced diabetic male rats. The male rats with average weight 200-220 g were divided into four groups (n=6), control, diabetic (induced with a single dose of streptozotocin (50 mg/kg body weight), T-1 and T-2 as treated diabetic with the two fractions of Ipomoea aquatica (IA6-1 and IA9-2), respectively. Biochemical evaluation of blood glucose, serum insulin and C-peptide were carried out. Histological examination of islets of Langerhans was done for cellular population changes. The results revealed that the oral consumption of two fractions of I. aquatica for 15 days, effective significantly reduced the fasting blood sugar level of streptozotocin-induced diabetic rats (p < 0.05). The percent changes were a 51% and 31% decrease in the serum glucose concentration of the diabetic rats when treated with the plant fractions of IA6-1 and IA9-2, respectively. Most biochemical parameters tested returned to nearly normal levels. Histologically, islets area and normal cell population were preserved in treated animals with superior results in T-1 and T-2 groups. In conclusion, fractions IA6-1 and IA9-2 showed potential antidiabetic effects when given orally to diabetic rats. The mechanism of action requires further investigation using both molecular and immunohistochemical methods investigation of both insulin secreting cells and insulin receptors. Future clinical trials could be tried using volunteers to confirm the present results so could be marketed as a supplement for diabetic patients. | ||||
| Keywords | ||||
| Ipomoea aquatica; Hypoglycemic activity; α-Amylase; C-peptide; Insulin | ||||
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