Synthesis of Some New Thieno[2,3-b]thiophene Derivatives and Prediction their Biological Activity by PASS INET | ||||
| Sohag Journal of Sciences | ||||
| Volume 7, Issue 2, May 2022, Page 9-13 PDF (791.26 K) | ||||
| Document Type: Regular Articles | ||||
| DOI: 10.21608/sjsci.2022.233419 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mahmoud Abd El Aleem Ali Ali El- Remailya   1; Elders Kh. Shokr2; H. Abdel-Ghany1; Moumen S. Kamel1; Omar. M. Elhady1; Ahmed M. Soliman1
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| 1Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt | ||||
| 2Physics Department, Faculty of Science, Sohag University, Sohag 82524, Egypt | ||||
| Abstract | ||||
| A series of thieno[2,3-b] thiophene moiety-containing bis-barbituric 2a,b and bis-pyrazoles 3-4a–b derivatives were synthesized and predict their biological activity using PASS INET. According to obtanied data the most frequently predicted, which they showed high biological activity predicted for a potential compound with the highest probability are oxidoreductase inhibitor, chemosensitizer, potassium channel large-conductance Ca-activated activator, Cystinyl aminopeptidase inhibitor and Neurotransmitter uptake inhibitor. | ||||
| Keywords | ||||
| Thieno[2; 3-b]thiophene – Pass predicition – Azo dye – PASS INET | ||||
| References | ||||
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