Upregulation of Long Non-coding RNA MEG3 and miR-181b in Type 2 Diabetic Patients with Cerebral Stroke | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 65, Issue 132, December 2022, Page 377-385 PDF (381.42 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.128273.5701 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Heba A. Hassan1; Naglaa M. Ammar1; Olfat G. Shaker2; Yasser I. Kandil 3; Mahmoud Gomaa Eldeib  3
| ||||
| 1Therapeutic Chemistry Department, National Research Centre (NRC), El-Bouth St., P.O. 12622 Cairo, Egypt | ||||
| 2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt | ||||
| 3Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt | ||||
| Abstract | ||||
| Background and Aims Several studies have demonstrated that long non-coding RNA (lncRNA) and microRNA (miRNA) molecules were closely related to the pathogenesis of diabetes mellitus (DM) and its complications. In this study, we aimed to explore the possible relationship of lncRNA MEG3 and miR-181b with the development of ischemic cerebral stroke (CS) as a complication of type 2 DM. Methods The study involved 20 diabetic patients (DM), 20 diabetic patients with CS (DM+CS), 17 CS patients and 10 apparently healthy subjects. The expression levels of MEG3 and miR-181b were analyzed in peripheral blood samples using real time PCR. Results The expression of MEG3 was significantly higher in both DM+CS and CS groups as compared to DM or control group. In addition, miR-181b was significantly upregulated in DM+CS and CS compared to control group. Conclusions This study suggested that MEG3 and miR-181b may play a role in the progression of CS in diabetic patients. | ||||
| Keywords | ||||
| Cerebral stroke; MEG3; miR-181b; type-2 diabetes mellitus | ||||
|
Statistics Article View: 500 PDF Download: 100 |
||||
