Studying the Ameliorative Effect of Bee Venom Against Damage and Inflammation Induced in Gamma-Irradiated Rats
Shaaban, A., Hamza, R., El shahat, A. (2019). Studying the Ameliorative Effect of Bee Venom Against Damage and Inflammation Induced in Gamma-Irradiated Rats. EKB Journal Management System, 52(1), 178-184. doi: 10.21608/ajnsa.2018.3107.1071
Ashraf Mohamed Mounir Shaaban; Refaat Galal Hamza; Amro Nagah El shahat. "Studying the Ameliorative Effect of Bee Venom Against Damage and Inflammation Induced in Gamma-Irradiated Rats". EKB Journal Management System, 52, 1, 2019, 178-184. doi: 10.21608/ajnsa.2018.3107.1071
Shaaban, A., Hamza, R., El shahat, A. (2019). 'Studying the Ameliorative Effect of Bee Venom Against Damage and Inflammation Induced in Gamma-Irradiated Rats', EKB Journal Management System, 52(1), pp. 178-184. doi: 10.21608/ajnsa.2018.3107.1071
Shaaban, A., Hamza, R., El shahat, A. Studying the Ameliorative Effect of Bee Venom Against Damage and Inflammation Induced in Gamma-Irradiated Rats. EKB Journal Management System, 2019; 52(1): 178-184. doi: 10.21608/ajnsa.2018.3107.1071

Studying the Ameliorative Effect of Bee Venom Against Damage and Inflammation Induced in Gamma-Irradiated Rats

Arab Journal of Nuclear Sciences and Applications
Article 19, Volume 52, Issue 1, January 2019, Page 178-184  XML PDF (547.61 K)
Document Type: Original Article
DOI: 10.21608/ajnsa.2018.3107.1071
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Authors
Ashraf Mohamed Mounir Shaaban email orcid 1; Refaat Galal Hamza2; Amro Nagah El shahat1
1Food irradiation department, Artificial irradiation division, NCRRT, Cairo, Egypt
2Food irradiation, Artificial irradiation division, NCRRT, Atomic energy authority, Cairo, Egypt
Abstract
The aim of this study was focused on investigating the possible protective effect of Bee Venom (BV) against gamma radiation induced damage and inflammation in male rats. Gamma-irradiation (6 Gy) resulted in a significant elevation in the level of tumor necrotic factor-alpha (TNF-α) , interleukin-6 (IL-6) , creatinine kinase-MB (CK-MB) and cardiac troponin I (cTnI), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), serum aspartate transaminase (AST) and alanine transaminase (ALT) , serum glucose, malondialdehyde (MDA) concentration and xanthine oxidase activity associated with remarkable decrease in insulin level, glutathione content (GSH) and the activity of xanthine dehydrogenase (XDH), superoxide dismutase (SOD) and catalase (CAT) in heart and liver tissues compared to control group. Injection of BV (5ml/kg b. wt. / day/6weeks) to γ-irradiated rats was found to offer protection against γ-irradiation induced oxidative stress and significantly ameliorated the changes occurred in the above investigated biochemical parameters. It could be concluded that Bee venom clarified a modulatory role against gamma radiation induced oxidative damage and inflammation in the heart and liver tissues.
Keywords
Bee venom; Gamma Irradiation; Inflammation; antioxidants
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