Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives
Salem, I., Mostafa, S., El-Sabbag, O., Ibrahim, T., Abdulrahmanf, A., Bendary, M. (2018). Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives. EKB Journal Management System, 2(2), 52-66. doi: 10.21608/rpbs.2018.23373
Ibrahim Mostafa Salem; Samia M. Mostafa; Osama I. El-Sabbag; Tarek S. Ibrahim; Ahmed Abdulrahmanf; Mahmoud M. Bendary. "Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives". EKB Journal Management System, 2, 2, 2018, 52-66. doi: 10.21608/rpbs.2018.23373
Salem, I., Mostafa, S., El-Sabbag, O., Ibrahim, T., Abdulrahmanf, A., Bendary, M. (2018). 'Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives', EKB Journal Management System, 2(2), pp. 52-66. doi: 10.21608/rpbs.2018.23373
Salem, I., Mostafa, S., El-Sabbag, O., Ibrahim, T., Abdulrahmanf, A., Bendary, M. Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives. EKB Journal Management System, 2018; 2(2): 52-66. doi: 10.21608/rpbs.2018.23373

Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives

Records of Pharmaceutical and Biomedical Sciences
Article 6, Volume 2, Issue 2, September 2018, Page 52-66  XML PDF (573.81 K)
Document Type: Original Article
DOI: 10.21608/rpbs.2018.23373
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Authors
Ibrahim Mostafa Salem email 1; Samia M. Mostafa2; Osama I. El-Sabbag3, 4; Tarek S. Ibrahim5, 6; Ahmed Abdulrahmanf7; Mahmoud M. Bendary8
1Pharmaceutical Chemistry Departement, Faculty of Pharmacy, Suez Canal University
2Pharmaceutical Chemistry Department, Suez Canal University, Faculty of Pharmacy, Ismailia, Egypt
3Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
4Pharmaceutical Chemistry Department, Faculty of Pharmacy, Taif University, Taif, Saudi Arabia
5Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
7Department of Pharmaceutical chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt
8Department of Microbiology and Immunology, Faculty of Pharmacy, Port Said University, Port Said, Egypt
Abstract
The aim of this study is to synthesize new benzenesulfonamide derivatives that possess antibacterial activity using Bumetanide as a precursor of benzenesulfonamide. A novel series of hydrazones containing benzenesulfonamides (4a-i) and 1,3,4 oxadiazole containing benzenesulfonamides (5a-e) were prepared and their antibacterial and antifungal activities were measured using microplate broth assay against Gram-positive: Staphylococcus aureus, Gram-negative: Escherichia coli and Pseudomonas aeruginosa and Fungi: Aspergillus fumigates and Candida albicans. The results showed that some of the prepared compounds exhibit a good to excellent activity against the mentioned bacteria, however all the series showed no activity against fungi. Among the series, Compound (4i) demoed an excellent antibacterial activity better than that of the standard reference (Sulfamethoxazole) against Escherichia coli, while compounds (4c, 4e, 4g) showed good activity against all tested bacterial strains equals to Sulfamethoxazole activity. Moreover, compounds (4g, 5d) exert an antimicrobial activity equals to that of Sulfamethoxazole against Pseudomonas aeruginosa, while compounds (4a, 4b, 4c, 4f, 4g, 4h) exhibit similar activity to Sulfamethoxazole against Escherichia coli.
Keywords
Bumetanide; Hydrazones; 1,3,4-oxadiazole; antimicrobial activity; benzenesulfonamide
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