The Effect of Different Concentrations of (R)-(+)-WIN 55,212-2 on Wound Healing of Chondrocytes Monolayer.
Abdeldayem, A., Yousseffi, M., Khaghani, S., Genedy, M., Denyer, M. (2011). The Effect of Different Concentrations of (R)-(+)-WIN 55,212-2 on Wound Healing of Chondrocytes Monolayer.. EKB Journal Management System, 14(AEROSPACE SCIENCES & AVIATION TECHNOLOGY, ASAT - 14 – May 24 - 26, 2011), 1-8. doi: 10.21608/asat.2011.23419
A. Abdeldayem; M. Yousseffi; S. A. Khaghani; M. Genedy; M. C.T. Denyer. "The Effect of Different Concentrations of (R)-(+)-WIN 55,212-2 on Wound Healing of Chondrocytes Monolayer.". EKB Journal Management System, 14, AEROSPACE SCIENCES & AVIATION TECHNOLOGY, ASAT - 14 – May 24 - 26, 2011, 2011, 1-8. doi: 10.21608/asat.2011.23419
Abdeldayem, A., Yousseffi, M., Khaghani, S., Genedy, M., Denyer, M. (2011). 'The Effect of Different Concentrations of (R)-(+)-WIN 55,212-2 on Wound Healing of Chondrocytes Monolayer.', EKB Journal Management System, 14(AEROSPACE SCIENCES & AVIATION TECHNOLOGY, ASAT - 14 – May 24 - 26, 2011), pp. 1-8. doi: 10.21608/asat.2011.23419
Abdeldayem, A., Yousseffi, M., Khaghani, S., Genedy, M., Denyer, M. The Effect of Different Concentrations of (R)-(+)-WIN 55,212-2 on Wound Healing of Chondrocytes Monolayer.. EKB Journal Management System, 2011; 14(AEROSPACE SCIENCES & AVIATION TECHNOLOGY, ASAT - 14 – May 24 - 26, 2011): 1-8. doi: 10.21608/asat.2011.23419

The Effect of Different Concentrations of (R)-(+)-WIN 55,212-2 on Wound Healing of Chondrocytes Monolayer.

International Conference on Aerospace Sciences and Aviation Technology
Article 104, Volume 14, AEROSPACE SCIENCES & AVIATION TECHNOLOGY, ASAT - 14 – May 24 - 26, 2011, May 2011, Page 1-8  XML PDF (714.95 K)
Document Type: Original Article
DOI: 10.21608/asat.2011.23419
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Authors
A. Abdeldayem1, 2; M. Yousseffi3; S. A. Khaghani1, 2; M. Genedy1, 2; M. C.T. Denyer2
1School of Engineering, Design & Technology-Medical Engineering.+
2Institute of Pharmaceutical Innovation, University of Bradford, West Yorkshire, BD7 1DP, UK.
3School of Engineering, Design & Technology-Medical Engineering.
Abstract
Number of studies has been conducted to highlight the anti-inflammatory and immunosuppressive properties of cannabinoids and also their potentials for prevention of cartilage degradation. Various wound healing techniques can be used to investigate the mechanisms of chondrocyte repair in monolayer or 3 dimensional tissue. Therefore, we investigated the effect of two different concentrations (0.6 and 0.9μg/ml) of the synthetic cannabinoid R (+) WIN55, 212-2 on the wound healing of chondrocyte monolayers using a simple scratch assay model. WIN55, 212-2 was found to increase both the migration and proliferation of chondrocytes cultured in a chondrogenic media, with increase in the wound closure rate. These findings highlight the potential use of the synthetic cannabinoid for improving the rate of wound closure as well as acting as an anti-inflammatory agent, which could be used to enhance tissue engineering protocols aimed at cartilage repair.
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