Evaluation of the Efficacy of Topically Applied Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis; Randomized Control Trail
Kotb, S., Abo Zaid, F., Salama, R., Zayed, G. (2022). Evaluation of the Efficacy of Topically Applied Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis; Randomized Control Trail. EKB Journal Management System, 5(1), 61-68. doi: 10.21608/aadj.2022.234723
Shaymaa H. Kotb; Fathey A. Abo Zaid; Ragaa H. Salama; Gamal M Zayed. "Evaluation of the Efficacy of Topically Applied Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis; Randomized Control Trail". EKB Journal Management System, 5, 1, 2022, 61-68. doi: 10.21608/aadj.2022.234723
Kotb, S., Abo Zaid, F., Salama, R., Zayed, G. (2022). 'Evaluation of the Efficacy of Topically Applied Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis; Randomized Control Trail', EKB Journal Management System, 5(1), pp. 61-68. doi: 10.21608/aadj.2022.234723
Kotb, S., Abo Zaid, F., Salama, R., Zayed, G. Evaluation of the Efficacy of Topically Applied Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis; Randomized Control Trail. EKB Journal Management System, 2022; 5(1): 61-68. doi: 10.21608/aadj.2022.234723

Evaluation of the Efficacy of Topically Applied Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis; Randomized Control Trail

Al-Azhar Assiut Dental Journal
Article 7, Volume 5, Issue 1 - Serial Number 33795, April 2022, Page 61-68  XML PDF (1.49 MB)
Document Type: Original Article
DOI: 10.21608/aadj.2022.234723
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Authors
Shaymaa H. Kotb* 1; Fathey A. Abo Zaid1; Ragaa H. Salama2; Gamal M Zayed3
1Department of Periodontology, Oral Diagnosis and Dental Radiology, Faculty of Dentistry, Al-Azhar University, Assuit, Egypt
2Department of Medical Biochemistry, Faculty of medicine, Assuit University, Assuit, Egypt
3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
Abstract
Aim: This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis. Subjects and Methods: Forty chronic periodontitis selected patients ,divided into two groups. Group I: included 20 chronic periodontitis patients, treated by conventional periodontal therapy SRP combined with intra- pocket application of Melatonin gel once weekly for 1 month begin application at the second week after initial therapy. Group II: included 20 chronic periodontitis patients, treated by SRP combined with the injection of placebo, weekly for one month. The periodontal parameters were recorded at baseline, 1week, 1and 3 months.Gingival crevicular fluid (GCF) samples were collected and a quantitative measurement of receptor activator nuclear K ligand (RANKL) was carried out by using Enzyme-Linked Immunosorbent Assay (ELISA) at baseline, 1week, 1 and 3 months. Results: We found noticeable significant reduction in all clinical parameter and in the amount of GCF RANKL in group I in all evaluation period at 1 ,3-month over group II. Conclusion: The results proved the benefit of Melatonin as a promising adjunctive therapy in improving periodontal parameters. However, further long-term studies with large sample size are needed..
Keywords
Chronic periodontitis; Gingival crevicular fluid; Melatonin; RANKL; ELISA
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