EFFECT OF DELTAMETHRIN ON DRUG METABOLIZING ENZYMES IN MALE MICE LIVER | ||||
| Journal of Plant Protection and Pathology | ||||
| Article 10, Volume 31, Issue 5, May 2006, Page 3247-3255 PDF (105.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jppp.2006.235224 | ||||
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| Author | ||||
| Sabah G. El-Banna. | ||||
| Department of Environmental Studies. Institute of Graduate Studies and Research. Alexandria University, 163 Horreya Avenue. P.O. Box 832, Alexandria 21526. Egypt. | ||||
| Abstract | ||||
| The present study was undertaken to investigate the effects of a single (24 h) and repeated (7 days) doses of deltamethrin (10 rngikg body weight daily) on hepatic drug metabolizing enzymes. The hepatic content of microsomal protein, cytochrome P450 and b5. activities of NADPH cytochrome C reductase, amidopyrine N—demethylase. aniline-4shydroxylase. glutathion S-transeferase and the level of thiobarbituric acid reactive substances (TEARS) were determined. The obtained results indicated that a single dose of deltamethrin had no significant effect on hepatic microsomal proteins, cytochrome b5, amidopyn‘ne N-demethylase, aniline-4- hydroxylase, or TEARS. However, it significantly decreased (p < 0.05) the activity of cytochrome P450. and increased the activities of NADPH cytochrome C reductase {p < 0.001) and glutathion S-transeferase (pit-0.05). Repeated doses of deltamethrin significantly decreased the activities of hepatic microsomal proteins (ps0.05) and amidopyrine N-demethylase (p¢0.001), and increased the activities (Ps0.01) of other studied enzymes. The obtained results indicated that single and repeated doses of deltamethrin had marked effects on hepatic drug metabolizing enzymes. | ||||
| Keywords | ||||
| Delamethrin; mice. hepatic microsomal enzymes. TBARS | ||||
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