Ameliorating effects of bovine colostrum on experimentally induced osteoporotic lumbar vertebrae in female albino rats: a histomorphomeric and scanning electron microscopic study.
Mohamed, H., Abdelmalek, A., Abdelaziz, H., Mikhaeel, G. (2022). Ameliorating effects of bovine colostrum on experimentally induced osteoporotic lumbar vertebrae in female albino rats: a histomorphomeric and scanning electron microscopic study.. EKB Journal Management System, 3(1), 7-28. doi: 10.21608/sjpms.2022.130354.1007
Heba Kamal Mohamed; Adel Kamel Abdelmalek; Hoda Ahmed Abdelaziz; Ghobrial Abdalla Mikhaeel. "Ameliorating effects of bovine colostrum on experimentally induced osteoporotic lumbar vertebrae in female albino rats: a histomorphomeric and scanning electron microscopic study.". EKB Journal Management System, 3, 1, 2022, 7-28. doi: 10.21608/sjpms.2022.130354.1007
Mohamed, H., Abdelmalek, A., Abdelaziz, H., Mikhaeel, G. (2022). 'Ameliorating effects of bovine colostrum on experimentally induced osteoporotic lumbar vertebrae in female albino rats: a histomorphomeric and scanning electron microscopic study.', EKB Journal Management System, 3(1), pp. 7-28. doi: 10.21608/sjpms.2022.130354.1007
Mohamed, H., Abdelmalek, A., Abdelaziz, H., Mikhaeel, G. Ameliorating effects of bovine colostrum on experimentally induced osteoporotic lumbar vertebrae in female albino rats: a histomorphomeric and scanning electron microscopic study.. EKB Journal Management System, 2022; 3(1): 7-28. doi: 10.21608/sjpms.2022.130354.1007

Ameliorating effects of bovine colostrum on experimentally induced osteoporotic lumbar vertebrae in female albino rats: a histomorphomeric and scanning electron microscopic study.

Sphinx Journal of Pharmaceutical and Medical Sciences
Volume 3, Issue 1, April 2022, Page 7-28  XML PDF (1.91 MB)
Document Type: Original research articles
DOI: 10.21608/sjpms.2022.130354.1007
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Authors
Heba Kamal Mohamed email 1; Adel Kamel Abdelmalek2; Hoda Ahmed Abdelaziz2; Ghobrial Abdalla Mikhaeel2
1Department of Anatomy, Faculty of Medicine, Assiut University, Egypt, Assiut
2Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abstract
Background: Up till now there is no efficient preventive and/or therapeutic treatment of osteoporosis which constitutes a worldwide tragedy especially in women after menopause.

Objectives: Is to investigate the ameliorating effect of the use of bovine colostrums in prevention and treatment of osteoporosis.

Materials and methods: 90 female albino rats were divided into two main groups; a sham operated control group (30 rats) and an experimental group (60 rats). The experimental group was subdivided into 4 subgroups (15 rats each): Subgroup IIa, rats were subjected to bilateral ovariectomy and received daily IM injection of methylprednisolone (1 mg / kg BW) for 3 months; Subgroup IIb, ovx rats received methylprednisolone (1 mg / kg BW) and concomitantly received daily bovine colostrum (1ml / day) for 3 months; Subgroup IIc ovx corticosteroid-treated rats left for further 3 months to reach 9 months old and Subgroup IId, ovx corticosteroid-treated rats received daily colostrum for 3 months. Lumbar vertebrae were exposed to X-ray and DEXA scan to assess bone densities. Decalcified specimens were processed for histomorphometric assessment as well as scanning electron microscopic evaluation of bone microarchitecture.

Results: Induction of osteoporosis resulted in disruption of ossification zones and significant decrease in BMD. Prophylactic group showed marked improvement of BMD and restoration of bone microarchitecture. Therapeutic group showed reasonable restoration of bone architecture and decrease in percentage of bone loss.

Conclusion: Colostrum significantly prevented bone derangement when used as a prophylactic and reasonably restored bone microarchitecture when used as therapeutic agent for treatment of osteoporosis.
Keywords
colostrum; osteoporosis; ovariectomy; corticosteroid
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