Bioevaluation of 99mTc-Pipazethate as a potential guide tracer for malignant tumor imaging. | ||||
| Arab Journal of Nuclear Sciences and Applications | ||||
| Article 12, Volume 55, Issue 3, July 2022, Page 108-117 PDF (687.01 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajnsa.2022.115910.1544 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
marwa Refaye  1; sabah Ibrahim Khater 2; dina El sharawy3
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| 1Radioactive isotopes and generators department, Hot Lab. Center, Egyptian Atomic Energy Authority, | ||||
| 2Radioactive Isotopes and Generators Department, Hot Labs. Center, Atomic Energy Authority, Egypt. | ||||
| 3Labeled Compounds Department, Hot Lab. Center, Egyptian Atomic Energy Authority. | ||||
| Abstract | ||||
| Diagnosis of tumor is one of the most important stages in the treatment, as good quality imaging and accurate analysis means to choose the right and more effective tracer. Therefore, the study of the ability of new radiopharmaceutical compound to track solid tumor became a pioneering field. Thus, the study of pipazethate as a possible solid tumor marker was in our scope. It was labeled with technetium reaching a (RCY) radiochemical yield of 96.5%, using SnCl2 .2H2O as a reducing agent. A biodistribution study of 99mTc-Pip in tumored mice was performed which revealed the capability of the complex to image solid tumor as it was accumulated in the tumor with a concentration of 13% at 30min (p.i) post injection T/NT ratio was considered, the ratio reached 2.9 at 30 min post-injection, and this value confirmed the high sensitivity and selectivity of 99mTc-Pip to tumor. 99mTc-Pip passed the (BBB) blood brain barrier reaching the brain in a concentration of 5.8g/tissue at 5 p.i in normal mice while reached to 5.5 g/tissue at 5 p.i in tumored mice. Finally, molecular modeling was applied for prediction of the most energetically stable structure of 99mTc-pip. | ||||
| Keywords | ||||
| Pipazethate; 99mTc; Solid tumor; Blood brain barrier; Molecular modeling | ||||
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