THERAPEUTIC EFFICACY OF ARTEMISIA ANNUA ETHANOL EXTRACT VERSUS ALBENDAZOLE ON MIGRATING & ENCYSTED TRICHINELLA SPIRALIS LARVAE IN MICE | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 7, Volume 52, Issue 1, May 2022, Page 45-52 PDF (1.38 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2022.235773 | ||||
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| Authors | ||||
| MUSLIMAH N. ALSULAMI1; YASSER M. MOHAMED2 | ||||
| 1Department of Biology, College of Science, University of Jeddah, Jeddah, Saudi Arabia | ||||
| 2Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Trichinellosis the gastro-intestinal (GI) and muscle (parenteral or systemic) are the 2 important phases of the parasite cycle. Infection with Trichinella spiralis is dangerous, and severe infections can be lethal affecting several organs including the liver and kidneys in addition to the final habitat which is the muscles. The several side effects limit the benzimidazole derivatives use. This study compared the antiparasitic action of ethanol extract of Artemisia annua against migrating and encysted T. spiralis larvae in in experimentally infected mice to the common helminthic used drug Albendazole®. Life cycle was developed in BALB/c mice by oral infection with 300muscle larvae. Mice were divided into four groups. Treatments with Albendazole and Artemisia annua ethanol extract were administered at the 15th day post infection (PI). On the 30th PI, they were sacrificed to evaluate the treatment, histopathologically of diaphragm, muscle, liver and kidneys to improvement. The Artemisia annua ethanol extract was as effective as Albendazole against the T. spiralis larvae. | ||||
| Keywords | ||||
| Trichinella spiralis; Larvae; Artemisia Annua; Albendazole; Histopathology | ||||
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