Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer
Ibrahim, H., Abdelrahman, A., Elwan, A., Elsebai, E., Eliwa, A., Elbasateeny, S. (2022). Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer. EKB Journal Management System, 28(6), 1414-1429. doi: 10.21608/zumj.2022.133357.2555
Hanaa Mohamed Ibrahim; Aziza E. Abdelrahman; Amira Elwan; Eman Ali Elsebai; Ahmed Eliwa; Samah S. Elbasateeny. "Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer". EKB Journal Management System, 28, 6, 2022, 1414-1429. doi: 10.21608/zumj.2022.133357.2555
Ibrahim, H., Abdelrahman, A., Elwan, A., Elsebai, E., Eliwa, A., Elbasateeny, S. (2022). 'Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer', EKB Journal Management System, 28(6), pp. 1414-1429. doi: 10.21608/zumj.2022.133357.2555
Ibrahim, H., Abdelrahman, A., Elwan, A., Elsebai, E., Eliwa, A., Elbasateeny, S. Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer. EKB Journal Management System, 2022; 28(6): 1414-1429. doi: 10.21608/zumj.2022.133357.2555

Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer

Zagazig University Medical Journal
Article 28, Volume 28, Issue 6, November 2022, Page 1414-1429  XML PDF (1.51 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2022.133357.2555
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Authors
Hanaa Mohamed Ibrahim1; Aziza E. Abdelrahman email orcid 2; Amira Elwan3; Eman Ali Elsebaiorcid 4; Ahmed Eliwaorcid 5; Samah S. Elbasateeny6
1Pathology faculty of medicine Zagazig university
2Pathology department, faculty of medicine, zagazig university, Egypt
3clinical oncology, faculty of medicine
4Clinical oncology department
5Urology department , Zagazig University
6pathology department,faculty of medicine,zagazig university,Egypt
Abstract
BACKGROUND: Despite advances in intravesical therapy and surgery, up to 30% of NMIBC suffer progression to MIBC.
OBJECTIVES: To identify the valuable prognostic biomarkers, we analyzed the immunohistochemical expression of Sox2, YAP1, and IMP3 in 60 cases of NMIBC who underwent TURBT with adjuvant intravesical bacillus-Calmette-Guerin (BCG).
METHODS: The immunohistochemical expression was done on a sixty patients who complained from primary papillary superficial transitional cell carcinoma (TCC) of the urinary bladder (Stage Ta-T1).Their predicting role for recurrence, progression, progression-free survival (PFS), and recurrence-free survival (RFS) was assessed.
RESULTS: High Sox2 expression was observed in 55% of NMIBC cases, and it was significantly associated with the tumor size, grade, and stage (p < /p>
Keywords
Sox2; YAP1; IMP3; Non-muscle-invasive bladder cancer; Prognostic markers
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