HEMATOLOGICAL AND BIOCHEMICAL STUDIES ON LEISHMANIA DONOVANI (ATCC®30030™) IN EXPERIMENTAL INFECTED MICE | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 18, Volume 52, Issue 1, May 2022, Page 145-152 PDF (919.44 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2022.235845 | ||||
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| Authors | ||||
| DINA M. M. EL-SHEWEHY1; MOHAMED FATHY ABOUEL-NOUR HEGAZY1; SHADIA FARID HAMADA1; Tosson Morsy2 | ||||
| 1Department of Zoology, Faculty of Science, Mansoura University, Egypt | ||||
| 2Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt | ||||
| Abstract | ||||
| Leishmaniasis is caused by Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow). It usually is more common in rural than in urban areas, but also in the outskirts of some cities. Cutaneous leishmaniasis usually heal on their own, even without treatment, but this can take months or even years leaving ugly scars. Mucosal leishmaniasis might not be noticed until years after the original sores healed. Ensuring adequate treatment of the cutaneous infection may help prevent mucosal leishmaniasis. Visceral form If not treated, severe or advanced cases are fatal. The pentavalent antimonial compounds; Pentostam® is the first line anti-Leishmania treatment. However, its effect on human body was not well evaluated as compared with two plants extracted (Black seed oil and Curcumin) with anti-parasitic activities. The effect of the three was studied in experimentally infected Swiss Albino mice | ||||
Highlights | ||||
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| Keywords | ||||
| Leishmania donovani (Atcc®30030™); Experimental infected mice; Treatment | ||||
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