EFFECT OF CARROT OIL SUPPLEMENTATION ON OXIDATIVE STRESS IN EXPERIMENTALLY-INDUCED HYPOTHYROIDISM AND HYPERTHYROIDISM IN ALBINO RATS | ||||
| Egyptian Journal of Zoology | ||||
| Article 11, Volume 62, Issue 62, December 2014, Page 229-254 | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.12816/0009345 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Eman S. Abdel Reheim  ; S. M. Abd El-Twab
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| Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt | ||||
| Abstract | ||||
| It is estimated that huge amount of ROS, especially of H2O2, are produced in the thyroid under physiological conditions, justifying the statement that the thyroid gland is an organ of “oxidative nature”. The present study is designed to evaluate the effect of carrot oil administration on hormonal & lipid profile, lipid peroxidation and antioxidant & minerals status in both hypothyroid and hyperthyroid male albino rats. Rats were rendered hyperthyroid by exogenous thyroxine (0.3 mg/kg body weight) and hypothyroid by carbimazole (20 mg/kg body weight). Then, these rats were orally administered carrot oil (100 mg/kg body weight) for 4 weeks. Thyroid stimulating hormone (TSH) showed its highest level with the hypothyroid group and its lowest level with the hyperthyroid group. Triiodothyonine (T3) and thyroxine (T4) levels were increased significantly in hyperthyroid group and deceased significantly in hypothyroid one in comparison with the control group. Both non enzymatic (reduced glutathione, GSH; vitamins E and C) and enzymatic (catalase, CAT; glutathione peroxidase, GSHPx; glutathione reductase, GSSGR; and glucose-6-phosphate dehydrogenase, G6PDH) antioxidant defenses were decreased in hepatic tissues of both hypothyroid and hyperthyroid rats. On the other hand, lipid peroxidation products increased significantly in these considered groups. The highest levels of triglyceride, total cholesterol, and bad lipoproteins (LDL- and vLDL-cholesterol) were recorded in hypothyroid group, whereas they showed lowest level in hyperthyroid one. Opposite change was observed in HDL-cholesterol level, where it achieved its highest level in hyperthyroid group and its lowest level in hypothyroid rats. Moreover, apolipoproteins (A and B) increased significantly in the hyperthyroid group and decreased in the hypothyroid group. In hyperthyroid rats, the serum levels of calcium, magnesium and zinc increased significantly and phosphorus level decreased significantly as compared to the control group. Reverse results were obtained in hypothyroid rats. Carrot oil administration improved the above mentioned alterations. These effects of carrot oil may help the improvement of hypo- and hyperthyroidisms and accompanied hepatic antioxidants defense system, but active compound searches should be proceeding in future. | ||||
| Keywords | ||||
| Carrot oil; Active constituents; Oxidative Stress; Hyperthyroidism; hypothyroidism; Rats | ||||
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