Preparation and Characterization of Terbutaline Sulphate-loaded Chitosan/Carbopol Nanoparticles | ||||
| Journal of Advanced Pharmacy Research | ||||
| Article 4, Volume 3, Issue 1, January 2019, Page 30-34 PDF (252.32 K) | ||||
| Document Type: Short Communication | ||||
| DOI: 10.21608/aprh.2019.6474.1071 | ||||
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| Authors | ||||
soha abd el-motelb  1; Mohamed Nasereldin2; Hanan Refai1
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| 1College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt. | ||||
| 2Department of Pharmaceutics, Faculty of Pharmacy, Helwan University, Helwan, Egypt. | ||||
| Abstract | ||||
| Objective: The objective of the present study is to prepare and evaluate terbutaline sulphate loaded chitosan/carbapol nanoparticles for treatment of asthma via nasal route. Methods: Nanoparticles were prepared by ionic gelation method with various concentrations of chitosan and carbopol. The developed Terbutaline sulphate-loaded chitosan/carbopol nanoparticles were analysed for particle size, dispersion homogeneity, zeta potential, entrapment efficiency, in vitro drug release and fourier transform infrared ray spectroscopy (FT-IR). Results: The sizes of all of the formulations which showed opalescent colloidal dispersions visually were in nanorange which was between 575.31 nm and 601.12 nm and entrapment efficiency ranged from 34.71 % to 40.04 % and zeta potential from -27.04 mV to -33.62 mV. All the CS/CP nanodispersions showed an initial burst release followed by a more gradual sustained release. The FT-IR studies suggested that an interaction between CS and TS during the formation of nanoparticles. Conclusion: CS/CP nanoparticles were successfully prepared by ionic gelation method and may also be useful for a variety of other therapeutic delivery systems. | ||||
| Keywords | ||||
| Carbopol; Chitosan; Nanoparticles | ||||
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