The Association of Prothrombin G20210 Gene Polymorphism and Risk of Thrombosis in B.Thalassemic Children in Egypt | ||||
Zagazig University Medical Journal | ||||
Article 28, Volume 30, Issue 2, March and April 2024, Page 513-521 PDF (751.43 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zumj.2022.128050.2526 | ||||
View on SCiNiTO | ||||
Authors | ||||
amal fawzy 1; mervat hesham 2; Adel Ali3; shimaa abougabal4; Hanim Abd elnour5 | ||||
1Medical Biochemistry Department- Faculty of Medicine - Zagazig University | ||||
2Pediatric Department, Faculty of Medicine, Zagazig University | ||||
3Faculty of Medicine, Zagazig University, Department of Pediatrics, Sharkia Egypt | ||||
4Pediatric Department ,Faculty of Medicine ,Zagazig University | ||||
5Medical Biochmestry Department, Faculty of Medicine, Zagazig Univerisity, Zagazig, Egypt | ||||
Abstract | ||||
Background: Hypercoagulable state is associated with thalassemic children with increased risk of thromboembolic events ,There are multiple factors are contributing to hypercoagulable state in thalassemia patient. Aim of the study: To assesses the prothrombin G20210A gene polymorphism in Egyptian thalassemic children being additional risk factor for thromboembolism in thalssemic children . Methods: This is a case control study. It included 40 thalassemic patients with thromboembolic manifistation and 40 healthy controls. The prothrombin gene polymorphism was identified using a restriction fragment length polymerase chain reaction (RFLP PCR). Results: No Significant difference in prothrombin G20210A genotype between Thalssemic patient with thrombotic manifistation and controls regarding allele and genotype distributions. (OR 3.2 , 95 % CI 0.57–17.89 and p=0.082 for AA genotype ). A allele was significantly related to cases (25% in cases in comparison to 12.5% in controls). Conclusion: prothrombin gene polymorphism has no role predisposition to thalassemic coagulability in thalassemic Egyptian children. | ||||
Keywords | ||||
Thalassemia; prothrombin gene; thromboembolism, polymorphism | ||||
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