he Asossiation Of Prothrombin G20210 Gene Polymorphism And Risk of Thrombosis in B.Thalassemic Children in Egypt

fawzy, amal; hesham, mervat; Ali, Adel Sherif; abougabal, shimaa; Abd elnour, Hanim Magdy

doi:10.21608/zumj.2022.128050.2526

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	he Asossiation Of Prothrombin G20210 Gene Polymorphism And Risk of Thrombosis in B.Thalassemic Children in Egypt
Zagazig University Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 12 May 2022
Document Type: Original Article
DOI: 10.21608/zumj.2022.128050.2526
Authors
amal fawzy ¹; mervat hesham ²; Adel Sherif Ali³; shimaa abougabal⁴; Hanim Magdy Abd elnour⁵
¹alkhshat street
²pediatric department, faculity of medicine, Zagazig university
³Faculty of Medicine, Zagazig University, Department of pediatrics, Sharkia Egypt
⁴pediatric depatment ,faculty of medicine ,zagazig university
⁵medical biochmestry and molecular biology department, faculty of medicine, Zagazig univerisity, Zagazig, Egypt
Abstract
Background: Hypercoagulable state is associated with thalassemic children with increased risk of thromboembolic events ,There are multiple factors are contributing to hypercoagulable state in thalassemia patient. Aim of the study: To assesses the prothrombin G20210A gene polymorphism in Egyptian thalassemic children being additional risk factor for thromboembolism in thalssemic children . Methods: This is a case control study. It included 40 thalassemic patients with thromboembolic manifistation and 40 healthy controls. The prothrombin gene polymorphism was identified using a restriction fragment length polymerase chain reaction (RFLP PCR). Results: No Significant difference in prothrombin G20210A genotype between Thalssemic patient with thrombotic manifistation and controls regarding allele and genotype distributions. (OR 3.2 , 95 % CI 0.57–17.89 and p=0.082 for AA genotype ). A allele was significantly related to cases (25% in cases in comparison to 12.5% in controls). Conclusion: prothrombin gene polymorphism has no role predisposition to thalassemic coagulability in thalassemic Egyptian children.
Keywords
Thalassemia; prothrombin gene; thromboembolism, polymorphism


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he Asossiation Of Prothrombin G20210 Gene Polymorphism And Risk of Thrombosis in B.Thalassemic Children in Egypt