Synthesis, Anticancer Activity, and Molecular Docking of New Furan-2-one and Pyrazole heterocycles Based on 5,6,7,8-Tetrahydronaphthalene
hamdy, N., Awad, H., Tarek, M., Mohamed, H. (2023). Synthesis, Anticancer Activity, and Molecular Docking of New Furan-2-one and Pyrazole heterocycles Based on 5,6,7,8-Tetrahydronaphthalene. EKB Journal Management System, 66(1), 15-29. doi: 10.21608/ejchem.2022.136816.6032
nehal aly ahmed hamdy; Hanem Awad; Mohammad M. Tarek; Hanan Mohamed. "Synthesis, Anticancer Activity, and Molecular Docking of New Furan-2-one and Pyrazole heterocycles Based on 5,6,7,8-Tetrahydronaphthalene". EKB Journal Management System, 66, 1, 2023, 15-29. doi: 10.21608/ejchem.2022.136816.6032
hamdy, N., Awad, H., Tarek, M., Mohamed, H. (2023). 'Synthesis, Anticancer Activity, and Molecular Docking of New Furan-2-one and Pyrazole heterocycles Based on 5,6,7,8-Tetrahydronaphthalene', EKB Journal Management System, 66(1), pp. 15-29. doi: 10.21608/ejchem.2022.136816.6032
hamdy, N., Awad, H., Tarek, M., Mohamed, H. Synthesis, Anticancer Activity, and Molecular Docking of New Furan-2-one and Pyrazole heterocycles Based on 5,6,7,8-Tetrahydronaphthalene. EKB Journal Management System, 2023; 66(1): 15-29. doi: 10.21608/ejchem.2022.136816.6032

Synthesis, Anticancer Activity, and Molecular Docking of New Furan-2-one and Pyrazole heterocycles Based on 5,6,7,8-Tetrahydronaphthalene

Egyptian Journal of Chemistry
Volume 66, Issue 1, January 2023, Page 15-29  XML PDF (2.3 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.136816.6032
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Authors
nehal aly ahmed hamdy1; Hanem Awadorcid 2; Mohammad M. Tarek3; Hanan Mohamed email 4
1applied organic chemistry , nrc
2Tanning Materials and Leather Technology Department, National Research Centre, Egypt
3Bioinformatics Department, Armed Forces College of Medicine (AFCM) Cairo, Egypt
4Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Center, Dokki, Giza, 12622 Egypt;
Abstract
Novel furan-2-one and pyrazole heterocycles incorporating 5,6,7,8-tetrahydronaphthalene moiety 4, 8, 10a-c, 12a-c and 13 were prepared starting from 2-acetyl tetralin via reaction with diethyl oxalate followed by cyclization using hydroxylamine hydrochloride, and hydrazine hydrate. Further treatment of carbohydrazide 8 with isatin derivatives 9a-c and hydrazonoyl halides 11a-c afforded N'-(5-subs.-2-oxoindolin-3-ylidene)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazole-5-carbohydrazides 10a-c and N'-aryl-2-(2-(3-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazole-5-carbonyl)hydrazono)propanehydrazonoyl chlorides 12a-c. The novel compounds were examined in vitro for their anti-tumor activities against HepG-2 and MCF-7 human carcinoma cell lines using MTT assay. Most compounds showed good to moderate activities against HepG-2 carcinoma cells and HepG-2 cells.
Keywords
2-Acetyl tetralin; Furan-2-ones; Pyrazoles; Anti-tumor activity
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