Design, Synthesis of Sulfadiazine Derivatives bearing Some New Heterocyclic Compounds with study Antimicrobial and Antioxidant Activity | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 2, February 2023, Page 81-91 PDF (1.29 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.131305.5787 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hala Shkyair Lihumis  ; Ameer Alameri ; Rawaa Zaooli
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| Department of Chemistry, College of science ,University of Babylon ,Iraq | ||||
| Abstract | ||||
| In this work new heterocyclic derivatives were prepared. The most available (Sulfadiazine) compound treated with different aromatic aldehydes to synthesis (F1-F5) imine derivatives then cycloaddition reaction of imines with phenylthioacetic acid to produced azetidin-2-one derivatives(F6,F7). compound F1 treated ethylene glycol and hydrazine to get (F8) . (F9,F10) compounds has been synthesis by reacting (F1) compound with maleic anhydride and phthalic anhydride in dry benzene . compound F8 treated p-hydroxy benzaldehyde to get (F11) compound. Reaction (F11) with benzoyl chloride gave (F12) compound. Also, (F12) compound treated with urea to get urease derivative .These synthesized compounds (F1-F13) evaluated for their antimicrobial activity and antioxidant activity. | ||||
| Keywords | ||||
| Sulfadiazine; imines; azetidin-2-one; benzaldehyde; antioxidant activity | ||||
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