Assessment of Serum 25-Hydroxy Vitamin D Level among Hypothyroidism Sudanese Patients with and without Thyroid Peroxidase Antibodies
Abdrabo, A., Wagea-Alla, D., Mustafa, H., Abdoalsamed, O., AbdEl-Majeed, A., Hussain, A. (2022). Assessment of Serum 25-Hydroxy Vitamin D Level among Hypothyroidism Sudanese Patients with and without Thyroid Peroxidase Antibodies. EKB Journal Management System, 28(5), 1016-1021. doi: 10.21608/zumj.2022.110368.2431
AbdElkarim Abobaker Abdrabo; Dalia Ibrahim Wagea-Alla; Hafiya Mustafa; Omsalama El-Sadiq Abdoalsamed; Azza Khalifa AbdEl-Majeed; Alaa Zainalabdeen Hussain. "Assessment of Serum 25-Hydroxy Vitamin D Level among Hypothyroidism Sudanese Patients with and without Thyroid Peroxidase Antibodies". EKB Journal Management System, 28, 5, 2022, 1016-1021. doi: 10.21608/zumj.2022.110368.2431
Abdrabo, A., Wagea-Alla, D., Mustafa, H., Abdoalsamed, O., AbdEl-Majeed, A., Hussain, A. (2022). 'Assessment of Serum 25-Hydroxy Vitamin D Level among Hypothyroidism Sudanese Patients with and without Thyroid Peroxidase Antibodies', EKB Journal Management System, 28(5), pp. 1016-1021. doi: 10.21608/zumj.2022.110368.2431
Abdrabo, A., Wagea-Alla, D., Mustafa, H., Abdoalsamed, O., AbdEl-Majeed, A., Hussain, A. Assessment of Serum 25-Hydroxy Vitamin D Level among Hypothyroidism Sudanese Patients with and without Thyroid Peroxidase Antibodies. EKB Journal Management System, 2022; 28(5): 1016-1021. doi: 10.21608/zumj.2022.110368.2431

Assessment of Serum 25-Hydroxy Vitamin D Level among Hypothyroidism Sudanese Patients with and without Thyroid Peroxidase Antibodies

Zagazig University Medical Journal
Article 14, Volume 28, Issue 5, September 2022, Page 1016-1021  XML PDF (439.31 K)
Document Type: Original Article
DOI: 10.21608/zumj.2022.110368.2431
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Authors
AbdElkarim Abobaker Abdrabo email orcid 1; Dalia Ibrahim Wagea-Alla2; Hafiya Mustafa3; Omsalama El-Sadiq Abdoalsamed3; Azza Khalifa AbdEl-Majeed3; Alaa Zainalabdeen Hussain3
1Department of clinical chemistry, Faculty of Medical Laboratory Science
2Department of Clinical chemistry, School of Medical Laboratory Science, Sharq Elniel College
3Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Sudan International University, Khartoum, Sudan.
Abstract
Background: The association between serum 25-Hydroxy vitamin D (25-OH vitamin D) level in hypothyroid subjects with and without thyroidperoxidase (TPO) antibodies is controversial. There is increasing evidence that 25-OH vitamin D level is associated with autoimmune diseases.
Objectives: To assess serum 25-OH vitamin D levels among hypothyroidism Sudanese patients with and without thyroid peroxidase (TPO) antibodies.
Materials and methods: analytical cross-sectional conducted at The Center for Diabetes and Endocrinology in Khartoum from February to October 2020. Sixty subjects with hypothyroidism were recruited from the follow-up clinic. Other sixty age and sex-matched subjects were selected as control. Thyroid function tests (TSH, FT4 and FT3) were measured using TOSOH AIA 360 system analyzer, serum 25-OH vitamin D level was measured using semiautomatic I-Chroma-II reader and thyroid peroxidase antibodies (TPO antibodies) were measured in both cases and controls using ELISA technique. The results were analyzed using SPSS version 21.
Result: TSH was significantly increased in both TPO antibodies positive and TPO antibodies negative hypothyroid subjects than the control (22.3±4.44), (10.5±2.55) (3.42±0.75), respectively, with P-value 0.000. Level of 25-OH Vitamin D was lower among hypothyroid subjects than the control. Subjects with positive TPO antibody had lower 25-OH vitamin D levels than the TPO-antibody negative subjects compared to control (7.45±4.50̽) (10.5±7.18) (48.8±10.0), respectively, with P-value 0.000. Females 46 (77%) were more than males 14(23%).
Conclusion: 25-OH vitamin D level was low in patients with hypothyroidism. Subjects with positive TPO-antibodies had lower serum 25-OH vitamin D compared to TPO-antibody negative subjects.
Keywords
Antithyroid Peroxidase (TPO); Vitamin D deficiency; Hypothyroidism
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