Role of Stem Cells and Erythropoietin on Experimental Acute Hepatic Injury in Rats | ||||
| Egyptian Academic Journal of Biological Sciences, B. Zoology | ||||
| Article 20, Volume 14, Issue 1, January 2022, Page 261-269 PDF (722.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsz.2022.238371 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Samir A. M. Zaahkouk1; Mansour, A.2; Ibrahim, Reda. Hassan1; Sawsan El-Shamy3 | ||||
| 1Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt | ||||
| 2Pharmacology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 3Biology Department, Basic Science, Misr University for Science and Technology, Cairo, Egypt. | ||||
| Abstract | ||||
| Erythropoietin (EPO) exhibits non- hematopoietic functions. Besides its hematopoietic functions, EPO has anti-apoptotic, anti-oxidant and anti-inflammatory activities. Tissue-protective EPO effect was confirmed in brain, myocardium, liver, and kidney injury. Mesenchymal stem cells (MSCs) are nonhematopoietic cells. It may be extracted from the bone marrow, dental pulp, adipose tissue, placenta, umbilical cord, or amniotic membrane. Pre-clinical and clinical evidence shows that MSCs derived can heal injured liver tissues, enhance liver functions, and reduce liver fibrosis. Material and Methods: Hundred male albino rats were classified into five groups equally. Some biochemical and Immunohistochemical studies of COX-2 were assessed in the liver tissue. Results: MSCs and EPO treatment ameliorated the toxic effect of GalN with a significant decrease in the mean level of ALAT, ASAT, and ammonia. The combination between MSCs and EPO showed more effective protection against GalN toxicity. | ||||
| Keywords | ||||
| Stem Cells; Erythropoietin; Hepatic Injury; rats | ||||
|
Statistics Article View: 167 PDF Download: 256 |
||||
