Assessment Of Anti-Inflammatory Cytokine Interleukin-10 In Mild Cognitive Impairment In Elderly
Ramadan, A., Mohamed, A., Tahoun, M., Tahoun, K., Arafa, M. (2022). Assessment Of Anti-Inflammatory Cytokine Interleukin-10 In Mild Cognitive Impairment In Elderly. EKB Journal Management System, 5(2), 249-263. doi: 10.21608/niles.2022.238416
Ali Mahmoud Ali Ramadan; Azza Hassan Mohamed; Mona Moustafa Tahoun; Kariman Abdelwahab Abdelhai Tahoun; Mohamed Hussein Arafa. "Assessment Of Anti-Inflammatory Cytokine Interleukin-10 In Mild Cognitive Impairment In Elderly". EKB Journal Management System, 5, 2, 2022, 249-263. doi: 10.21608/niles.2022.238416
Ramadan, A., Mohamed, A., Tahoun, M., Tahoun, K., Arafa, M. (2022). 'Assessment Of Anti-Inflammatory Cytokine Interleukin-10 In Mild Cognitive Impairment In Elderly', EKB Journal Management System, 5(2), pp. 249-263. doi: 10.21608/niles.2022.238416
Ramadan, A., Mohamed, A., Tahoun, M., Tahoun, K., Arafa, M. Assessment Of Anti-Inflammatory Cytokine Interleukin-10 In Mild Cognitive Impairment In Elderly. EKB Journal Management System, 2022; 5(2): 249-263. doi: 10.21608/niles.2022.238416

Assessment Of Anti-Inflammatory Cytokine Interleukin-10 In Mild Cognitive Impairment In Elderly

NILES journal for Geriatric and Gerontology
Article 2, Volume 5, Issue 2, June 2022, Page 249-263  XML PDF (497.22 K)
Document Type: Original Article
DOI: 10.21608/niles.2022.238416
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Authors
Ali Mahmoud Ali Ramadan email orcid 1; Azza Hassan Mohamed2; Mona Moustafa Tahoun3; Kariman Abdelwahab Abdelhai Tahoun2; Mohamed Hussein Arafa2
1Department of Internal Medicine, Faculty of Medicine, University of Alexandria, Alexandria, Egypt
2Department of Internal Medicine, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
3Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt
Abstract
Background: Mild cognitive impairment (MCI) is decline and disturbance of cognitive, little impairment of complex skills, ability to conduct ordinary daily functions, and the absence of dementia are all features of MCI. Interleukin-10 (IL-10) has anti-inflammatory effects and may suppress neurodegenerative disorders.
Objective: This study aimed to investigate the possible association between serum interleukin 10 (IL-10) levels and mild cognitive impairment (MCI) in the elderly population.
Material and methods: The study was carried out on 90 subjects aged 65 years or older] divided into Group I (MCI patients): including 45 patients. in Group II (Control): which included 45 subjects with normal cognition. All subjects underwent detailed history taking, clinical examination, and assessment of cognitive function. Laboratory investigations included: Serum interleukin-10(IL-10), C-reactive protein (CRP), ESR, CBC, fasting blood glucose (FBS), postprandial blood glucose (PPS), urea, creatinine, and liver enzyme levels.
Results: IL-10 levels in the MCI group ranged from 4.60 – 16.31 with a mean value (S.D) of 9.75 ± 2.26. IL-10 among the control group ranged from 4.91 – to 12.15 with a mean value (S. D) of 8.87 ± 1.80.IL-10 was significantly higher among the MCI group (p=0.044)
Conclusion: There was a statistically significant difference between the serum levels of IL-10 in patients with MCI and controls.
Keywords
Mild cognitive impairment (MCI); Inflammation; Interleukin 10(IL-10)
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