Protective effect of spirulina fusiform in chronic colitis in male albino rats | ||||
| Benha Medical Journal | ||||
| Article 246, Volume 39, Special issue (Academic), September and October 2022, Page 214-228 PDF (852.3 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2022.18446.1111 | ||||
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| Authors | ||||
reham ettesh  1; heba alnoury2; yasmeen ismail2; Mary Yacoub3
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| 1pharmacology, faculty of medicine ,kafr-elshekh university, fuwa,egypt | ||||
| 2pharmacology,faculty of medicine ,benha,benha | ||||
| 3Clinical Pharmacology,Faculty of medicine, Benha university,Benha ,Benha . | ||||
| Abstract | ||||
| Background/Objectives: In this work, a modified low dose model of induction of ulcerative colitis was used including the administration of single intra-rectal instillation of 1 ml of 5% acetic acid followed by 2% dextran sodium sulfate for 7 days. Moreover, aqueous suspension of Spirulina (500 mg /kg stomach gavage)was prophylactically used 7 days before disease induction . Antioxidant, anti-inflammatory effect was achieved by spirulina . Aim: The aim of this study was to determine the effectiveness of spirulina as a new, safe in treatment of ulcerative colitis Material and methods: Chronic UC was induced by 1ml 5% intracolonic acetic acid instillation in adult male albino rats as single dose following by adding 2% DSS orally in drinking water for 7 days. Intragastric administration of spirulina. (500 mg/kg/day) was administrated 7 days before acetic acid instillation and continued for the end of the experiment. Disease activity index (DAI), colonic oxidative stress markers, tumor necrosis factor (TNF)-a levels, IL1B, and the colonic histopathological changes were observed. Results: spirulina attenuated the severity of the acetic acid -DSS induced colitis through improving the DAI, the colonic oxidative stress markers, TNF-a, IL1B, morphological and partially ameliorate all histopathological changes. Conclusion: Therapeutically, spirulina could be administered in chronic colitis as potent antioxidant compounds and anti-inflammatory effect of phyocyanin will become a therapeutic strategy of choice for UC to improve the quality of life if sufficient clinical trials are available. Keywords: spirulina,oxidative stress, tumor necrosis factor . | ||||
| Keywords | ||||
| spirulina; oxidative stress; tumor necrosis factor | ||||
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