COMPARATIVE HISTOPATHOGENIC AND TOXICOLOGICAL EVALUATION OF IN VIVO EXPOSURE TO CHLORPYRIFOS AND ALDICARB IN MALE WISTAR RATS | ||||
| Journal of Plant Protection and Pathology | ||||
| Article 12, Volume 30, Issue 12, December 2005, Page 8201-8216 PDF (232.89 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jppp.2005.239491 | ||||
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| Author | ||||
| Salwa M. Abd-AlIah, | ||||
| Mammalian Toxicology Dept., Central Agric. Pesticides Laboratory, ARC, Alexandria | ||||
| Abstract | ||||
| The toxicological endpoints after chlorpyrifos and atdicarb exposure coupled with histological and ultrastructural examinations of multiorgan damage were assessed in the current study. The tested pesticides were applied orally in acute and subchronic manner to male Wistar rats at concentrations represent 1/3 and 1/10 LD;c; respectively. Animals under subchroruc intoxication were treeteo dally for 28 day. Signs of toxicity morbidity and mortality patterns were observed In a dose-dependent manner. Hepatic-injury marked by significant elevation in serum indicator enzymes (p < O.001) after acute and subchrcnic exposures was shown in a type, dose and time-dependent manner. The effect exerted by aldicarb was more pronounced than cnlorpvrttos either after acute or subchronic exposure. Kidneys showed signs of renal damage and nephropathy after exposure to both pesticides and a Significant association (p < O.01) was observed between the length of exposure and level of damage. However, liver appears to be more sensitive to the effect of the tested pesticides where histological signs of liver hypertrophy were apparent and lesions were correlated with biochemical endpoints. The study provides evidence of both functional and ultrastructural damage elicited by acute and subchronic exposure to aldicarb and chlorpyrifos. | ||||
| Keywords | ||||
| Oral toxicity; cblorpyritos; aldicarb; biochemistry; histopathology | ||||
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