Effect of Spirulina (Spirulina platensis) on Blood Glucose Level and Renal Impairment in Diabetic Rats | ||||
| Egyptian Journal of Nutrition and Health | ||||
| Volume 16, Issue 2, 2021, Page 53-69 PDF (768.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejnh.2021.239556 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Naeem M. Rabeh; Nafisa H. El-Banna; Khaled A. El- Kady; Nancy M.T. Ghonim | ||||
| Nutrition and Food Science Department, Faculty of Home Economics, Helwan University. | ||||
| Abstract | ||||
| Spirulina (S. platensis) is a blue-green alga with medicinal and nutritional interest due to its richness in nutrientsas well as acts a hepatoprotective, nephroprotective, and antioxidant activities. This study aimed to examine the effect of spirulina against streptozotocin (STZ) induced hyperglycemic associated with kidney impairment in rats. Thirty-five rats were randomly divided into two main groups: The first main group (n= 7) were fed on basal diet onlyduring the experiment and kept as the negative control group (-ve), the second main group " induced diabetic rats" (n=28) were divided into four subgroups as follow: the first subgroup was fed on basal diet and served as a positive control group (+ve). Groups (2, 3 and 4) were fed on basal diet supplemented with dried spirulina at the level of 2.5%, 5% and 7 %, respectively. At the end of the experimental period (8 weeks), rats were sacrificed and blood samples were collected to obtain serum. The results indicated that spirulina contains proteins (56.80 %) and fat (8.16 %) in addition to several minerals and vitamins. Spirulina supplementation significantly increase the final body weight, feed efficiency ratio and body weight gain % values compared to the +ve control rats. Diabetic treated rats had a significant increase (P<0.05) in insulin concentration and lower glucose levels as well as an improvement in kidney functions. Besides, spirulina significantly (P<0.05) reduced serum lipid profile, diminished the Malondahyde and enhanced glutathione peroxidase concentrations. Conclusion: The findings suggest that oral spirulina platensis could have a potential protective role for managing induced painful diabetic neuropathy in rats. | ||||
| Keywords | ||||
| Spirulina; diabetes; oxidative stress; glucose; lipid profile | ||||
|
Statistics Article View: 173 PDF Download: 369 |
||||
