AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA
Mohamed, W., Abdel-Hakim, A., Zakherah, M., El-Badawy, O., Hassan, E. (2022). AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA. EKB Journal Management System, 45(1), 389-399. doi: 10.21608/bfsa.2022.239580
Wegdan A Mohamed; Alshimaa G. Abdel-Hakim; Mahmoud Zakherah; Omnia El-Badawy; Ehsan A. Hassan. "AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA". EKB Journal Management System, 45, 1, 2022, 389-399. doi: 10.21608/bfsa.2022.239580
Mohamed, W., Abdel-Hakim, A., Zakherah, M., El-Badawy, O., Hassan, E. (2022). 'AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA', EKB Journal Management System, 45(1), pp. 389-399. doi: 10.21608/bfsa.2022.239580
Mohamed, W., Abdel-Hakim, A., Zakherah, M., El-Badawy, O., Hassan, E. AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA. EKB Journal Management System, 2022; 45(1): 389-399. doi: 10.21608/bfsa.2022.239580

AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA

Bulletin of Pharmaceutical Sciences Assiut University
Article 32, Volume 45, Issue 1, June 2022, Page 389-399  XML PDF (659.86 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2022.239580
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Authors
Wegdan A Mohamed1; Alshimaa G. Abdel-Hakim email 2; Mahmoud Zakherah3; Omnia El-Badawy1; Ehsan A. Hassan1
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt
2Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut University, Assiut, Egypt
3Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
During pregnancy, the key determinant to pregnancy success is the response of the maternal immune system towards the semi-allogeneic fetus. The pregnant uterus produces numerous cytokines such as interleukin (IL)-10 and transforming growth factor-beta (TGF-β) that are of critical importance from an immune perspective due to their immunosuppressive properties. Specific B cells can have a regulatory function in addition to their humoral activity. Pre-eclampsia (PE) is a syndrome that arises in 4%–8% of pregnancies and defined as new-onset proteinuria and hypertension after 20 weeks gestation. PE is characterized by maternal endothelial dysfunction caused by circulating fetal-derived factors from the placenta. The American College of Obstetricians and Gynecologists (ACOG) 2020 described the diagnostic criteria of PE as elevated systolic blood pressure to 140 mm Hg or higher or elevated diastolic blood pressure to 90 mm Hg or higher measured at least 4 hours apart on two occasions after 20 weeks of gestation in a formerly normotensive woman. In the pathophysiology of PE, B cells are a major player. A number of studies have linked abnormal B cell numbers and functions to obstetric problems.
Keywords
Normal pregnancy; Preeclampsia (PE); B cell subsets
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