T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 33, Volume 45, Issue 1, June 2022, Page 401-409 PDF (634.29 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2022.239581 | ||||
![]() | ||||
Authors | ||||
Yasmien H. Abdel-moneam ![]() ![]() | ||||
1Department of Microbiology & Immunology, Faculty of Pharmacy, Assuit University, Assuit, Egypt | ||||
2Department of Microbiology & Immunology, Faculty of Medicine, Assuit University, Assuit, Egypt | ||||
3Department of Internal Medicine, Faculty of Medicine, Assuit University, Assuit, Egypt | ||||
Abstract | ||||
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder distinguished by the presence of autoantibodies causing multiorgan damages. Follicular regulatory T (Tfr) cells are mainly located in germinal centers (GCs) and play vital role in inducing Tfh suppression, sustaining B cell tolerance and inhibiting autoantibodies development. Dysregulated Tfr cells result in abnormal GCs responses and contribute to the pathogenesis of autoimmune diseases. However, the exact role of Tfr cells in SLE is still ambiguous. The present review focuses on the immunological bases and the disturbed balance of Tfr and Tfh cells in autoimmune diseases, particularly SLE. In addition to the new therapeutic strategies for SLE. | ||||
Keywords | ||||
SLE; autoimmune diseases; innate immunity; Tfr; Tfh | ||||
Statistics Article View: 126 PDF Download: 141 |
||||