INVESTIGATING BACTERIA ISOLATED FROM DIABETIC FOOT ULCERS AND STUDYING THEIR SENSITIVITY TO ANTIBIOTICS –SYRIA
Al Abbas, L., Khaddam, W., Shreibati, F. (2022). INVESTIGATING BACTERIA ISOLATED FROM DIABETIC FOOT ULCERS AND STUDYING THEIR SENSITIVITY TO ANTIBIOTICS –SYRIA. EKB Journal Management System, 45(1), 451-458. doi: 10.21608/bfsa.2022.239586
Lara Atassi Al Abbas; Walid Khaddam; Fahd Shreibati. "INVESTIGATING BACTERIA ISOLATED FROM DIABETIC FOOT ULCERS AND STUDYING THEIR SENSITIVITY TO ANTIBIOTICS –SYRIA". EKB Journal Management System, 45, 1, 2022, 451-458. doi: 10.21608/bfsa.2022.239586
Al Abbas, L., Khaddam, W., Shreibati, F. (2022). 'INVESTIGATING BACTERIA ISOLATED FROM DIABETIC FOOT ULCERS AND STUDYING THEIR SENSITIVITY TO ANTIBIOTICS –SYRIA', EKB Journal Management System, 45(1), pp. 451-458. doi: 10.21608/bfsa.2022.239586
Al Abbas, L., Khaddam, W., Shreibati, F. INVESTIGATING BACTERIA ISOLATED FROM DIABETIC FOOT ULCERS AND STUDYING THEIR SENSITIVITY TO ANTIBIOTICS –SYRIA. EKB Journal Management System, 2022; 45(1): 451-458. doi: 10.21608/bfsa.2022.239586

INVESTIGATING BACTERIA ISOLATED FROM DIABETIC FOOT ULCERS AND STUDYING THEIR SENSITIVITY TO ANTIBIOTICS –SYRIA

Bulletin of Pharmaceutical Sciences Assiut University
Article 38, Volume 45, Issue 1, June 2022, Page 451-458  XML PDF (638.92 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2022.239586
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Authors
Lara Atassi Al Abbas email 1; Walid Khaddam1; Fahd Shreibati2
1Department of Biochemistry and Microbiology, Faculty of Pharmacy, AL Baath University, Homs, Syria
2Department of Surgery, Faculty of Medicine, AL Baath University, Homs, Syria
Abstract
The aim of this study was to investigate bacteria isolated from diabetic foot ulcers (DFUs), and determine their antibiotic sensitivity patterns that helps clinicians to select appropriate antimicrobial therapy. The study included 65 patients with DFUs who were admitted to Al-Basel Hospital in Homs, Syria between May 2020 and December 2020. Bacteria were isolated from foot lesions and identified by colonial morphology, gram staining and biochemical reactions. Antibiotic sensitivity of isolates was determined using the Kirby-Bauer disk diffusion method. A total of 89 bacterial isolates were obtained from 63 patients. Gram-positive bacteria were more common (58%) than gram-negative bacteria (42%). Staphylococcus aureus was the most prevalent isolate (29%), followed by Pseudomonas aeruginosa (13%) and Streptococcus agalactiae (11%). The antibiotic imipenem was the most effective against both gram-positive and gram-negative bacteria. In addition to imipenem, vancomycin and linezolid were the most effective antibiotics against gram-positive bacteria, while gentamicin and amikacin were the most effective antibiotics against gram-negative bacteria. This study showed low levels of sensitivity to self-administered antibiotics. Therefore, there is a need to avoid excessive use of antibiotics and improve antimicrobial stewardship programs.
Keywords
diabetic foot ulcers; sensitivity patterns; antimicrobial stewardship
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