HEPATOPROTECTIVE EFFECTS OF VITAMIN C AGAINST METHOTREXATE INDUCED ACUTE LIVER INJURY: AN EXPERIMENTAL STUDY | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 39, Volume 45, Issue 1, June 2022, Page 459-468 PDF (802.37 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2022.239624 | ||||
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| Authors | ||||
Ali Al-Gareeb; Ghaith F. Mohammed  
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| Department of Pharmacology, College of Medicine, University of Al-Mustansiriya, Baghdad-Iraq | ||||
| Abstract | ||||
| Methotrexate (MTX), a synthetic antimetabolite with a wide range of therapeutic indications, although its liver toxicity induced mainly through oxidative stress limits its clinical use. Vitamin C (ascorbic acid) possesses potent antioxidant and anti-inflammatory properties, Therefore, has a possible hepatoprotective effect. This study seeks to address the hepatoprotective effects of vitamin C against MTX-induced liver injury in albino mice. MTX showed significant elevation in both serum Alanine aminotransferase (ALT) and liver tissue Malondialdehyde (MDA), indicating hepatic injury, while vitamin C pre-treatment will hold down this elevation significantly and dose-dependently, causing amelioration of the toxic effect of MTX; the histopathological findings also support this finding. Also, MTX causes consumption of liver tissue content of superoxide dismutase (SOD) and Glutathione (GSH), while vitamin C pre-treatment boosts the SOD hepatic tissue level while GSH is diminished even more. In conclusion, vitamin C has a dose-dependent amelioration effect on the toxic effect of MTX on the liver. | ||||
| Keywords | ||||
| methotrexate; vitamin C; hepatotoxicity; liver; oxidative stress | ||||
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