Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma
ElKady, M., Elkholy, H., Ismail, Y., El Sayed, A. (2022). Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma. EKB Journal Management System, 39(2), 515-528. doi: 10.21608/bmfj.2022.118011.1534
Mostafa ElKady; Hany Elkholy; Yasser Ismail; Ahmed Mohamed El Sayed. "Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma". EKB Journal Management System, 39, 2, 2022, 515-528. doi: 10.21608/bmfj.2022.118011.1534
ElKady, M., Elkholy, H., Ismail, Y., El Sayed, A. (2022). 'Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma', EKB Journal Management System, 39(2), pp. 515-528. doi: 10.21608/bmfj.2022.118011.1534
ElKady, M., Elkholy, H., Ismail, Y., El Sayed, A. Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma. EKB Journal Management System, 2022; 39(2): 515-528. doi: 10.21608/bmfj.2022.118011.1534

Neuropilin1 as a diagnostic marker for Hepato-cellular Carcinoma

Benha Medical Journal
Article 16, Volume 39, Issue 2, July and August 2022, Page 515-528  XML PDF (758.79 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2022.118011.1534
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Authors
Mostafa ElKady1; Hany Elkholy1; Yasser Ismail2; Ahmed Mohamed El Sayed email 3
1Hepatology, Gastroenterology and Infectious Disease Department, Faculty of Medicine, Banha Universty
2Clinical and Chemical Pathology Department, Faculty of Medicine, Banha Universty
3M.B.B.CH, Ministry of Health, Kafr Shokr Central Hospital
Abstract
Background: Hepatocellular carcinoma (HCC) is a global health problem. It is the second most common cause of cancer-related mortality and the sixth most common cause of cancer worldwide, HCC development risk factors include chronic viral hepatitis, alcoholic and non-alcoholic fatty liver disorders and other forms of chronic hepatitis inflammatory illnesses ,The aim: to study the clinical usefulness of serum Neuropilin 1(NRP 1) as a diagnostic marker for HCC. Methods: This cross-sectional study was conducted on 90 individuals divided into three groups: Group I: Thirty patients with HCC, Group II: Thirty patients with liver cirrhosis(LC), Group III: Thirty apparently healthy subjects. All patients were subjected to full medical history taking, thorough clinical examination and determination of the serum level of NRP 1. Results; NRP1 level was significantly higher in HCC when compared to LC group. Also, NRP 1 level was significantly higher in HCC and LC groups when compared to control group. ROC curve of serum NRP1 showed sensitivity was 93.3%, specificity 80%, PPV of 82.4% and NPV of 92.3% with AUC of 0.842 at cutoff value of 4030 pg/ml. Conclusion: NRP-1 may represent a potential diagnostic marker for HCC
Keywords
Neuropilin1; Hepatocellular; Carcinoma; HCC
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