Amelioration of Alzheimer's disease with extracts of Punica granatum and Persea americana in AlCl3 induced rats
Ali, A., El-Hallouty, S., El-Desouky, M. (2023). Amelioration of Alzheimer's disease with extracts of Punica granatum and Persea americana in AlCl3 induced rats. EKB Journal Management System, 66(2), 21-32. doi: 10.21608/ejchem.2022.122759.5503
Abeer Abd El-Monaem Ali; Salwa Mohamed El-Hallouty; Mohamed Aly El-Desouky. "Amelioration of Alzheimer's disease with extracts of Punica granatum and Persea americana in AlCl3 induced rats". EKB Journal Management System, 66, 2, 2023, 21-32. doi: 10.21608/ejchem.2022.122759.5503
Ali, A., El-Hallouty, S., El-Desouky, M. (2023). 'Amelioration of Alzheimer's disease with extracts of Punica granatum and Persea americana in AlCl3 induced rats', EKB Journal Management System, 66(2), pp. 21-32. doi: 10.21608/ejchem.2022.122759.5503
Ali, A., El-Hallouty, S., El-Desouky, M. Amelioration of Alzheimer's disease with extracts of Punica granatum and Persea americana in AlCl3 induced rats. EKB Journal Management System, 2023; 66(2): 21-32. doi: 10.21608/ejchem.2022.122759.5503

Amelioration of Alzheimer's disease with extracts of Punica granatum and Persea americana in AlCl3 induced rats

Egyptian Journal of Chemistry
Volume 66, Issue 2, February 2023, Page 21-32  XML PDF (1.05 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.122759.5503
View on SCiNiTO View on SCiNiTO
Authors
Abeer Abd El-Monaem Ali1; Salwa Mohamed El-Halloutyorcid 2; Mohamed Aly El-Desouky email orcid 3
1Biochemistry Division,Chemistry Department, Faculty of Science,Cairo University,Egypt
2Drug Bioassay Cell Culture Laboratory, Pharmaceutical Sciences Division, National Research Center
3Biochemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt
Abstract
Background:Alzheimer's disease is a neurological disease that progresses over time. It is defined by the presence of both extracellular amyloidbeta (Ab) plaques, which are primarily made up of deposited Ab, and intracellular neurofibrillary tangles, which are made up of hyperphosphorylated and abnormally phosphorylated tau protein.Aim:This study aimed to investigate the role of Punica granatum and Persea americana extracts as an agent to decrease neurodegenerative effects of AlCl3 toxicity in male rats..Methods:42 male rats were divided in to seven experimental groups . G1 is the negative control group, and G2 is the positive control group.,G3,G4 and G5 received Alcl3(17 mg/kgb.w.)oral daily for one month and treated with Punica granatum extract (40 mg/kg b.w.),Persea americana extract (33.3 mg/kg b.w.) for three months and reference drug aricept(0.4 mg/kg b.w.)2 weeks of taking it orally respectively.Results: The mean level of dopamine in brain tissue in positive control decreased signeficantly compared to negative control. Brain caspase 3 and DNA fragmentation were significantly elevated.The treatment of punica granatum and persea americana extracts alleviated the adverse effect of AlCl3 in the treated groups and enhanced the dopamine level and declined apoptotic markers. conclusion :Punica granatum and Persea americana has an impact to minimize neurodegenerative effect of AD.
Keywords
Alzheimer disease (AD); Punica granatum; Persea americana; dopamine; caspase 3
Statistics
Article View: 387
PDF Download: 257