Comparison of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by Optical Coherence Tomography
Khalil, H., Ahmed, A., Mahfouz Eliwa, H. (2022). Comparison of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by Optical Coherence Tomography. EKB Journal Management System, 3(2), 226-242. doi: 10.21608/ejmr.2022.240903
Hossam El din Khalil; Abdel Rahman Shaaban Ahmed; Hassan Mostafa Mahfouz Eliwa. "Comparison of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by Optical Coherence Tomography". EKB Journal Management System, 3, 2, 2022, 226-242. doi: 10.21608/ejmr.2022.240903
Khalil, H., Ahmed, A., Mahfouz Eliwa, H. (2022). 'Comparison of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by Optical Coherence Tomography', EKB Journal Management System, 3(2), pp. 226-242. doi: 10.21608/ejmr.2022.240903
Khalil, H., Ahmed, A., Mahfouz Eliwa, H. Comparison of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by Optical Coherence Tomography. EKB Journal Management System, 2022; 3(2): 226-242. doi: 10.21608/ejmr.2022.240903

Comparison of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by Optical Coherence Tomography

Egyptian Journal of Medical Research
Article 16, Volume 3, Issue 2, April 2022, Page 226-242  XML PDF (496.56 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.240903
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Authors
Hossam El din Khalil; Abdel Rahman Shaaban Ahmed; Hassan Mostafa Mahfouz Eliwa
Department of Ophthalmology, Faculty of Medicine, Beni-Suef University
Abstract
Background: Diabetic macular edema (DME) can occur at any stage of non-proliferative and proliferative diabetic retinopathy. It is characterized by a swelling of the macular area that normally accounts for high-resolution visual acuity (VA), and DME therefore leads to visual deterioration.
Objective: To compare the effect of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by OCT. Patients and Methods: This was a prospective comparative study conducted on 32 Diabetic macular edema (DME); to compare the effect of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by OCT. Results: Pre-operative BCVA had a highly significant positive correlation with post-operative BCVA (p < 0.0001). DM duration had a highly significant negative correlation with post-operative BCVA (p = 0.0002). Logistic regression analysis shows that; after applying (Forward method) and entering some predictor variables; the decrease in DM duration; had an independent effect on increasing the probability of patient’s visual acuity improvement; with significant statistical difference (p = 0.042). By using ROC-curve analysis, Aflibercept and Ranibizumab usage showed non-significant predictive values in discrimination of improved patients from patients worsened ones (p > 0.05). Conclusion: Both aflibercept and ranibizumab improve visual acuity and decrease CMT in eyes with DME and moderate visual loss with no difference between the two drugs.
Keywords
Diabetic macular edema; visual acuity
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