Effect of Glyphosate on Male Fertility, Cytogenicity and Biochemical Parameters in Rats
ElEkhnawy, K., Abd-Elazzim, K., Faisal, R., kotb, N. (2018). Effect of Glyphosate on Male Fertility, Cytogenicity and Biochemical Parameters in Rats. EKB Journal Management System, 4(2), 13-20. doi: 10.21608/ejceh.2018.241065
K. E. ElEkhnawy; KM Abd-Elazzim; Ragaa asr Faisal; Nahla SH. kotb. "Effect of Glyphosate on Male Fertility, Cytogenicity and Biochemical Parameters in Rats". EKB Journal Management System, 4, 2, 2018, 13-20. doi: 10.21608/ejceh.2018.241065
ElEkhnawy, K., Abd-Elazzim, K., Faisal, R., kotb, N. (2018). 'Effect of Glyphosate on Male Fertility, Cytogenicity and Biochemical Parameters in Rats', EKB Journal Management System, 4(2), pp. 13-20. doi: 10.21608/ejceh.2018.241065
ElEkhnawy, K., Abd-Elazzim, K., Faisal, R., kotb, N. Effect of Glyphosate on Male Fertility, Cytogenicity and Biochemical Parameters in Rats. EKB Journal Management System, 2018; 4(2): 13-20. doi: 10.21608/ejceh.2018.241065

Effect of Glyphosate on Male Fertility, Cytogenicity and Biochemical Parameters in Rats

Egyptian Journal of Chemistry and Environmental Health
Volume 4, Issue 2, November 2018, Page 13-20  XML PDF (366.42 K)
Document Type: Scientific and Research
DOI: 10.21608/ejceh.2018.241065
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Authors
K. E. ElEkhnawy* 1; KM Abd-Elazzim1; Ragaa asr Faisal2; Nahla SH. kotb2
1Animal Health Research Institute
2EFSA on biologicals
Abstract
Oral administration of round up in rats doses of 49 and 490 mg/kg b.wt. daily for 65 successive days respectively, significantly decreased the weight of sexual organs, sperm cell concentration and sperm motility while the sperm abnormalities were increased. The levels of creatinine, cholesterol, uric acid and bilirubin in serum were significantly increased.Round up significantly increased the activities of serum AST, ALT and AP. The tested herbicide showed mutagenic potential as measured by a positive response in the micronucleus assay. The small dose tested caused slight toxicity to the bone marrow proliferation as determined by insignificant increased rate of bone marrow cells while the large dose significantly increased the rate of bone marrow proliferation as determined by the increase the rate of ratio in tested groups over that of the control. 
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