Epidemiological, Familial, and Biological Profile of Breast Cancer in a Population of Women in Oran | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 37, Volume 14, Issue 1, June 2022, Page 435-449 PDF (955.96 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2022.241254 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Derkaoui Dalia Kheira 1; Dali- Ali Abdessamad2; Ammour Fatima3; Hacene Fatima4; Chami Amina5; Habour Narimane6; Khiati Nadia7
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| 1Biology department, Faculty of Sciences, University Oran 1 Ahmed Benbella, | ||||
| 2Epidemiology department, Faculty of Medicine Hospital establishment EHU and CHU. Oran University Oran 1 Ahmed Benbella | ||||
| 3Epidemiology department, Faculty of Medicine Hospital establishment EHU and CHU. Oran University Oran 1 Ahmed Benbella. | ||||
| 4Pathology department, Faculty of Medicine Hospital establishment EHU Oran University Oran 1 Ahmed Benbella | ||||
| 5Biology department, Faculty of Sciences, University Oran 1 Ahmed Benbella. | ||||
| 6Biology department, Faculty of Sciences, University Oran 1 Ahmed Benbella | ||||
| 7Pharmacy Department, Faculty of Medicine Hospital establishment EHU. Oran University Oran 1 Ahmed Benbella. | ||||
| Abstract | ||||
| Breast cancer (BC) is the most common cancer in women worldwide and in developed countries, with approximately two million new cases of cancer diagnosed in 2018, it is a real public health problem. and the major cause of morbidity and mortality worldwide. Breast oncogenesis remains poorly understood, it is a multifactorial pathology for which the prognosis and the response to treatment differ from one patient to another, all these parameters represent a major obstacle in the management of BC.Many epidemiological studies on risk factors have been performed, it turns out that KS is a heterogeneous disease with data strongly supporting different associations of risk factors. Improved biological tools have made it possible to individualize different subtypes of breast cancer, as well as established biomarkers, including hormone receptor (HR), estrogen receptor (ER), progesterone receptor (PR), human epidermal growth receptor-2 (HER-2), and Ki67 labeling index. The existence of familial forms of breast cancer has been known for a long time and the notion of familiarity or heredity of breast cancer is at the origin either of a genetic alteration, or due to the presence of breast cancer in the family. The objective of our work is to identify the epidemiological, genetic and/or family and biological profile of breast cancer in women from western Algeria, in order to prevent the spread of this disease in Algeria and to be able to apply a diagnosis. early To meet our objectives, we proceeded with a retrospective study carried out at the level of the departments, of anatomopathology, oncology, epidemiology and preventive medicine of the EHU Oran hospital. | ||||
| Keywords | ||||
| Breast cancer; Epidemiology; Heredity; Risk factors; Biomarkers; Oran | ||||
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